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Welcome to Diabetologia

Diabetologia publishes original clinical and experimental research within the field of diabetes. We are interested in papers that convey new information or insight into any aspect of the condition, ranging from basic science to clinical applications. These are judged in terms of their scientific quality, novelty, relevance and interest to our broadly based readership.

Statement of Principle

We, as representatives of scientific organizations devoted to improving health care and advancing research, reaffirm that it is the mission of our respective medical journals to report and disseminate data from scientific investigation, evolving medical care, and innovative treatments. We believe these reports serve to unite basic scientists, clinical investigators, and medical professionals regardless of their country of origin, ethnic group, or political leaning. We believe that these efforts achieve the common goal of advancing scientific discoveries that lead to improved health of people worldwide. On the basis of our goals and principles, our respective journals will refrain from publishing articles addressing political issues that are outside of either research funding or health care delivery.

William T. Cefalu, MD, Editor in Chief, Diabetes Care
Juleen Zierath, PhD, Editor in Chief, Diabetologia
K. Sreekumaran Nair, MD, PhD, Editor in Chief, Diabetes
Derek LeRoith, MD, PhD, Editor in Chief, Endocrine Practice
Elizabeth R. Seaquist, MD, President, Medicine and Science, American Diabetes Association
Andrew J.M. Boulton, MD, President, European Association for the Study of Diabetes
R. Mack Harrell, MD, President, American Association of Clinical Endocrinologists
George Grunberger, MD, President Elect, American Association of Clinical Endocrinologists
Leonard Wartofsky, MD, Editor in Chief, The Journal of Clinical Endocrinology and Metabolism
Andrea C. Gore, PhD, Editor in Chief, Endocrinology
Margaret Wierman, MD, Acting Editor in Chief, Endocrine Reviews
Stephen R. Hammes, MD, PhD, Editor in Chief, Molecular Endocrinology
Carol A. Lange, PhD, Editor in Chief, Hormones and Cancer

In the News

Genetic deletion of Wdr13 improves the metabolic phenotype of Leprdb/db mice by modulating AP1 and PPARγ target genes

Download this new research by Dr Satish Kumar from DBT-National Institute of Animal Biotechnology, Hyderabad, India and colleagues.
For further information contact Dr Singh (satishk@niab.org.in).


(posted online 10.00 h GMT Friday 21 November 2014)

Current issue: December 2014

December 2014 cover

Click here to view this month's contents

The cover image shows a coloured scanning electron micrograph of common salt, sodium chloride, recrystallised from distilled water. In the present issue of Diabetologia, Premilovac and colleagues report that a diet high in salt causes insulin resistance in rodents. This stems from a loss of insulin sensitivity in the microvascular network within skeletal muscle, despite increased insulin signalling in both muscle and liver cells. These findings add further support to the hypothesis that impaired glucose delivery to skeletal muscle contributes to the early pathogenesis of insulin resistance.

Cover credit: POWER AND SYRED/SCIENCE PHOTO LIBRARY

Download the high resolution cover image

Up front

Juleen Zierath

Competition for publication in Diabetologia is greater than ever, and less than 20% of papers are accepted. Of all the high-quality papers that appear in this month's issue I want to share with you five articles that I find to be of particular interest. These will be featured 'up front' in the print issue and here on our website. Juleen R. Zierath, Editor


A systematic review of metabolite profiling in gestational diabetes mellitus
by Jennifer Huynh, Grace Xiong, Rhonda Bentley-Lewis

Metabolomics is a relatively new 'omics'-based approach that provides a snapshot of the metabolic status of a biological system. Recent metabolomics studies describing biomarker associations with gestational diabetes mellitus (GDM) have yielded conflicting results. In this issue, Huynh et al provide a systematic review of the literature on the use of metabolomics in the prediction, diagnosis and management of GDM. They report that asymmetric dimethylarginine and NEFA are the biomarkers most consistently associated with GDM, but further data from larger populations with more racial/ethnic diversity are needed. Improved first-trimester biomarkers would allow early risk stratification and the implementation of strategies to optimise maternal and fetal health. [Text supplied by the authors.]

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Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes
by Sophia Zoungas, Mark Woodward, Qiang Li, Mark E. Cooper, Pavel Hamet, Stephen Harrap, Simon Heller, Michel Marre, Anushka Patel, Neil Poulter, Bryan Williams, John Chalmers, for the ADVANCE Collaborative group

Data regarding the associations between age, age at diagnosis of diabetes, diabetes duration and subsequent vascular complications are inconsistent. In this issue, Zoungas et al present the results of an analysis of data from the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial and report that age (or age at diagnosis) and duration of diabetes were linked to the risk of death and macrovascular complications, whereas only diabetes duration was linked to the risk of microvascular complications. Strikingly, people diagnosed with type 2 diabetes at a younger age were at greater risk of microvascular complications than those who were older when they were diagnosed. These findings suggest that a refocus towards intensive management of hyperglycaemia at diagnosis of type 2 diabetes, particularly in younger people, may be warranted to minimise the long-term risk of microvascular complications. Further research is needed to determine the best strategies for achieving and maintaining optimal glucose control in people with diabetes diagnosed at a young age. [Text supplied by the authors.]

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Pre-pregnancy fried food consumption and the risk of gestational diabetes mellitus: a prospective cohort study
by Wei Bao, Deirdre K. Tobias, Sjurdur F. Olsen, Cuilin Zhang

Fried foods are commonly consumed worldwide, but few studies have examined how frequent fried food consumption is related to health. In this issue, Bao et al report their findings from an analysis of data on 15,027 women included in the Nurses' Health Study II cohort. They found that the risk of gestational diabetes (GDM) was almost doubled among women who ate fried foods regularly (≥7 times/week) compared with those who consumed fried foods less than once a week; this was not fully explained by body adiposity and other major risk factors of GDM. Interestingly, consuming fried foods regularly away from home was significantly related to an increased risk, but doing so at home was not. Since GDM is related to long-term adverse health outcomes in both women and their children, women of reproductive age may want to consider limiting their fried food intake to reduce their risk of GDM. [Text supplied by the authors.]

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Contrasting associations of insulin resistance with diabetes, cardiovascular disease and all-cause mortality in the elderly: PROSPER long-term follow-up
by Paul Welsh, David Preiss, Suzanne M. Lloyd, Anton J. de Craen, J. Wouter Jukema, Rudi G. Westendorp, Brendan M. Buckley, Patricia M. Kearney, Andrew Briggs, David J. Stott, Ian Ford, Naveed Sattar

The idea that insulin resistance in non-diabetic individuals might be a risk factor for cardiovascular disease is commonly promoted, but evidence to support this is sparse, particularly in the elderly. In this issue, Welsh et al use data from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) cohort to show that, as expected, those with higher insulin resistance (as measured by HOMA-IR) were substantially more likely to develop diabetes over 3 years of follow-up. However, there was no association of insulin resistance with risk of all-cause death or cardiovascular-specific death, even over an extended follow-up period of 8 years. These findings challenge the concept that insulin resistance is an important risk factor for death or cardiovascular disease in the elderly. [Text supplied by the authors.]

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Autocrine activation of P2Y1 receptors couples Ca2+ influx to Ca2+ release in human pancreatic beta cells
by Shara Khan, Richard Yan-Do, Eric Duong, Xichen Wu, Austin Bautista, Stephen Cheley, Patrick E. MacDonald, Matthias Braun

ATP is best known as a cellular energy source, but it also acts as a neurotransmitter within islets to help fine-tune insulin secretion. In this issue), Khan and Yan-Do et al present the results of a study investigating the effects of purinergic receptor agonists and antagonists on membrane potential, membrane electrical currents, intracellular calcium concentration and insulin secretion in human beta cells. They report that ATP acts as a positive signal in human beta cells by activating the P2Y1 receptor, stimulating electrical activity and controlling intracellular calcium stores. This positive feedback possibly causes the beta cells to respond faster and release more insulin. These findings increase the understanding of pancreatic islets biology. Further research in this area could lead to new ways of controlling insulin secretion in diabetes. This article is the subject of a commentary in this issue by Anders Tengholm. [Text supplied by the authors.]

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Inside this issue

In Memoriam

Douglas L. Coleman, 1931–2014
Thomas R. Coleman

Matthias Braun, 23 July 1966–16 November 2013
Patrik Rorsman, Quan Zhang

Commentaries

A dysglycaemic effect of statins in diabetes: relevance to clinical practice?
Daniel I. Swerdlow, Naveed Sattar

Purinergic P2Y1 receptors take centre stage in autocrine stimulation of human beta cells
Anders Tengholm

The emerging role of oestrogen-related receptor γ as a regulator of energy metabolism
Varman T. Samuel

Meta-analysis

Statins and glycaemic control in individuals with diabetes: a systematic review and meta-analysis
Sebhat Erqou, C. Christine Lee, Amanda I. Adler

Systematic Review

A systematic review of metabolite profiling in gestational diabetes mellitus
Jennifer Huynh, Grace Xiong, Rhonda Bentley-Lewis


Articles

Clinical Science and Care

Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes
Sophia Zoungas, Mark Woodward, Qiang Li, Mark E. Cooper, Pavel Hamet, Stephen Harrap, Simon Heller, Michel Marre, Anushka Patel, Neil Poulter, Bryan Williams, John Chalmers, for the ADVANCE Collaborative group

HARMONY 4: randomised clinical trial comparing once-weekly albiglutide and insulin glargine in patients with type 2 diabetes inadequately controlled with metformin with or without sulfonylurea
Peter N. Weissman, Molly C. Carr, June Ye, Deborah T. Cirkel, Murray Stewart, Caroline Perry, Richard Pratley

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Epidemiology

Pre-pregnancy fried food consumption and the risk of gestational diabetes mellitus: a prospective cohort study
Wei Bao, Deirdre K. Tobias, Sjurdur F. Olsen, Cuilin Zhang

Pregnancy glycaemia and cord-blood levels of insulin and leptin in Pakistani and white British mother–offspring pairs: findings from a prospective pregnancy cohort
Debbie A. Lawlor, Jane West, Lesley Fairley, Scott M. Nelson, Raj S. Bhopal, Derek Tuffnell, Dilys J. Freeman, John Wright, Donald C. Whitelaw, Naveed Sattar

Fertility is reduced in women and in men with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium (T1DGC)
Short Communication
Julia C. Wiebe, Angelo Santana, Nathan Medina-Rodríguez, Marta Hernández, Javier Nóvoa, Dídac Mauricio, Ana M. Wägner, on behalf of the T1DGC

N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in older patients with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
Anna H. Price, Paul Welsh, Christopher J. Weir, Insa Feinkohl, Christine M. Robertson, Joanne R. Morling, Stela McLachlan, Mark W. J. Strachan, Naveed Sattar, Jackie F. Price

Contrasting associations of insulin resistance with diabetes, cardiovascular disease and all-cause mortality in the elderly: PROSPER long-term follow-up
Paul Welsh, David Preiss, Suzanne M. Lloyd, Anton J. de Craen, J. Wouter Jukema, Rudi G. Westendorp, Brendan M. Buckley, Patricia M. Kearney, Andrew Briggs, David J. Stott, Ian Ford, Naveed Sattar

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Genetics

Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes
Christiane Winkler, Jan Krumsiek, Florian Buettner, Christof Angermüller, Eleni Z. Giannopoulou, Fabian J. Theis, Anette-Gabriele Ziegler, Ezio Bonifacio

Association of physical activity with lower type 2 diabetes incidence is weaker among individuals at high genetic risk
Yann C. Klimentidis, Zhao Chen, Amit Arora, Chiu-Hsieh Hsu

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Islet Studies

Autocrine activation of P2Y1 receptors couples Ca2+ influx to Ca2+ release in human pancreatic beta cells
Shara Khan, Richard Yan-Do, Eric Duong, Xichen Wu, Austin Bautista, Stephen Cheley, Patrick E. MacDonald, Matthias Braun

Inhibition of beta cell growth and function by bone morphogenetic proteins
Christine Bruun, Gitte L. Christensen, Marie L. B. Jacobsen, Marianne B. Kanstrup, Pernille R. Jensen, Helle Fjordvang, Thomas Mandrup-Poulsen, Nils Billestrup

Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action
Erica P. Cai, Cynthia T. Luk, Xiaohong Wu, Stephanie A. Schroer, Sally Yu Shi, Tharini Sivasubramaniyam, Jara J. Brunt, Eldad Zacksenhaus, Minna Woo

Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitors
Brigid Gregg, Lynda Elghazi, Emilyn U. Alejandro, Michelle R. Smith, Manuel Blandino-Rosano, Deena El-Gabri, Corentin Cras-Méneur, Ernesto Bernal-Mizrachi

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Metabolism

PKB/Akt phosphorylation of ERRγ contributes to insulin-mediated inhibition of hepatic gluconeogenesis
Don-Kyu Kim, Yong-Hoon Kim, Debby Hynx, Yanning Wang, Keum-Jin Yang, Dongryeol Ryu, Kyung Seok Kim, Eun-Kyung Yoo, Jeong-Sun Kim, Seung-Hoi Koo, In-Kyu Lee, Ho-Zoon Chae, Jongsun Park, Chul-Ho Lee, Sudha B. Biddinger, Brian A. Hemmings, Hueng-Sik Choi

A vascular mechanism for high-sodium-induced insulin resistance in rats
Dino Premilovac, Stephen M. Richards, Stephen Rattigan, Michelle A. Keske

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Research Letters

A 3-year follow-up of the Silent Diabetes Study
Oliver Schnell, Rolf Doerr, Volker Lodwig, Joerg Weissmann, Tobias Lohmann

Characterisation of glomerular haemodynamic responses to SGLT2 inhibition in patients with type 1 diabetes and renal hyperfiltration
Marko Škrtic, Gary K. Yang, Bruce A. Perkins, Nima Soleymanlou, Yuliya Lytvyn, Maximilian von Eynatten, Hans J. Woerle, Odd Erik Johansen, Uli C. Broedl, Thomas Hach, Melvin Silverman, David Z. I. Cherney

Letters

Protein ‘pre-loads’ in type 2 diabetes: what do we know and what do we need to find out?
Christopher K. Rayner, Jing Ma, Karen L. Jones, Peter M. Clifton, Michael Horowitz

Eighteen year weight trajectories and metabolic markers of diabetes in modernising China: which timescale is most relevant?
Dorte Vistisen, Kristine Færch

Eighteen year weight trajectories and metabolic markers of diabetes in modernising China: which timescale is most relevant? Reply to Vistisen D and Færch K [letter]
Annie Green Howard, Penny Gordon-Larsen, Elizabeth Koehler, Lauren Paynter, Amanda L. Thompson, Linda S. Adair, Bing Zhang, Amy H. Herring