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Welcome to Diabetologia

Diabetologia publishes original clinical and experimental research within the field of diabetes. We are interested in papers that convey new information or insight into any aspect of the condition, ranging from basic science to clinical applications. These are judged in terms of their scientific quality, novelty, relevance and interest to our broadly based readership.

Statement of Principle

EASD releases joint Statement of Principle with ADA, AACE and TES (November 2014)

In the News

A cancer diagnosis makes diabetes patients less adherent to their prescribed diabetes drugs

Download this new research by Marjolein Zanders, Netherlands Comprehensive Cancer Organisation, Eindhoven, the Netherlands, Jeffrey Johnson, School of Public Health, University of Alberta, Edmonton, Canada and colleagues.
For further information contact Ms Zanders (M.Zanders@iknl.nl) and Dr Johnson (jeffreyj@ualberta.ca).


(posted online 22.01 h GMT Wednesday 28th January 2014)



Current issue: February 2015

February 2015 cover

Click here to view this month's contents

The cover picture shows a coloured 3-D CT scan of the chest and abdomen of a kidney transplant patient. New-onset diabetes after transplant (NODAT) is a complication that can occur after kidney transplantation. In the present issue of Diabetologia, Gaynor et al report that, in contrast to previous reports, there was no unfavourable prognostic influence of NODAT in a prospectively followed, single-centre cohort of 628 adult primary kidney transplant recipients who underwent the procedure during 2000–2009.





Cover credit: ANTOINE ROSSET/SCIENCE PHOTO LIBRARY

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Up front

Juleen Zierath

Competition for publication in Diabetologia is greater than ever, and less than 20% of papers are accepted. Of all the high-quality papers that appear in this month's issue I want to share with you five articles that I find to be of particular interest. These will be featured 'up front' in the print issue and here on our website. Juleen R. Zierath, Editor


Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery
by Deanna M. Arble, Darleen A. Sandoval, Randy J. Seeley

Bariatric surgical procedures, such as Roux-en-Y gastric bypass and vertical sleeve gastrectomy, are currently the most effective treatment option for achieving significant and sustained weight loss. Nevertheless, current understanding of these procedures remains limited. In this issue, Arble et al review how rodent models have revealed new insights into the physiological systems governing obesity and glucose regulation. Researchers using these models have reported that bile acid signalling and alterations in the gut microbial community contribute to the potent effects of bariatric surgical procedures, which not only reduce weight but also improve metabolism in a weight-independent manner. Continued use of these translational animal models has the potential to reveal new targets for the treatment of obesity and diabetes. [Text supplied by the authors.]

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GLUT2, glucose sensing and glucose homeostasis
by Bernard Thorens

Multiple processes are involved in the maintenance of glucose homeostasis. Members of the glucose transporter (GLUT) protein family, comprising 14 isoforms, play distinct roles in these processes. In this issue, Bernard Thorens discusses information gathered from mouse and human studies that elucidate the role of GLUT2 in different organs, including the pancreas. Recent genetic, electrophysiological and optogenetic studies indicate that GLUT2 is involved in glucose sensing in nerve cells and the control of energy homeostasis, as well as in regulating the number and function of pancreatic islet alpha and beta cells. These findings may help unravel the molecular underpinnings of the associations of GLUT2 (also known as SLC2A2) variants with impaired fasting glucose and increased risk of progression to type 2 diabetes in humans. [Text supplied by the authors.]

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Sex-specific differences in diabetes prevention: a systematic review and meta-analysis
by Anna Glechner, Jürgen Harreiter, Gerald Gartlehner, Sonja Rohleder, Alexander Kautzky, Jaakko Tuomilehto, Megan van Noord, Angela Kaminski-Hartenthaler, Alexandra Kautzky-Willer

Lifestyle and pharmacological interventions have a beneficial preventive effect on the development of type 2 diabetes and weight gain in men and women with prediabetes. In this issue, Glechner, Harreiter et al present results of a meta-analysis of previously published and original sex-specific data, including more than 5,500 men and 7,400 women. No statistically significant differences in treatment effects during 1–6 years of active interventions could be detected between men and women. The authors conclude that despite differences in age of onset, detection and burden of type 2 diabetes between men and women, sex does not influence the effectiveness of preventive interventions in individuals with prediabetes. Consequently, clinicians can focus on factors that are known to influence the magnitude of beneficial effects, such as adherence. Clinicians also need to focus on other aspects of differences between men and women, such as the higher incidence of type 2 diabetes in middle-aged men and gaps in the quality of care between diabetic men and women. [Text supplied by the authors.]

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Low-energy diets differing in fibre, red meat and coffee intake equally improve insulin sensitivity in type 2 diabetes: a randomised feasibility trial
by Bettina Nowotny, Lejla Zahiragic, Alessandra Bierwagen, Stefan Kabisch, Jan B. Groener, Peter J. Nowotny, Ann Kristin Fleitmann, Christian Herder, Giovanni Pacini, Iris Erlund, Rikard Landberg, Hans-Ulrich Haering, Andreas F.H. Pfeiffer, Peter P. Nawroth, Michael Roden

High consumption of fibre and coffee and low intake of red meat associate with diminished risk of type 2 diabetes in epidemiological studies. Yet, whether these nutritional modifications also ameliorate the key abnormalities of overt type 2 diabetes, i.e. insulin resistance and insulin deficiency, is unclear. In this issue, Nowotny, Zahiragic et al report that low-energy diets with identical macronutrient compositions, but different amounts of fibre, red meat and coffee, reduce body weight and improve insulin sensitivity to the same extent. Although the lower risk diet rich in fibre and coffee tended to reduce subclinical inflammation, energy restriction was the driving force behind the improvement of insulin action during periods of active weight loss. These findings support the clinical recommendation of overall energy restriction, rather than making sophisticated changes to diet composition, to lower body weight and improve insulin sensitivity in the treatment of type 2 diabetes. [Text supplied by the authors.]

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Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells
by Haiqiang Dou, Changhe Wang, Xi Wu, Lijun Yao, Xiaoyu Zhang, Sasa Teng, Huadong Xu, Bin Liu, Qihui Wu, Quanfeng Zhang, Meiqin Hu, Yeshi Wang, Li Wang, Yi Wu, Shujiang Shang, Xinjiang Kang, Lianghong Zheng, Jin Zhang, Matthieu Raoux, Jochen Lang, Qing Li, Jing Su, Xiao Yu, Liangyi Chen, Zhuan Zhou

In pancreatic beta cells, insulin release is regulated by Ca2+ and cAMP. In this issue, Dou et al investigate the relationship between these two second messengers using combined live-cell fluorescence resonance energy transfer (FRET) imaging and patch-clamp recordings. They report that membrane depolarisation/glucose-induced Ca2+ influx increases cAMP/protein kinase A (PKA) pathway activity and promotes vesicle pool replenishment. In addition, knockdown of adenylyl cyclase 8 diminishes depolarisation-induced PKA activity and impairs sustained insulin secretion, suggesting a key role for this enzyme. Thus, Ca2+ influx appears to cause insulin secretion by directly triggering vesicle fusion (for instant release) and indirectly promoting vesicle pool replenishment (for sustained release) via PKA. These findings support a mechanism for sustained insulin secretion in response to a prolonged stimulus under physiological and diabetic conditions. [Text supplied by the authors.]

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Inside this issue

Commentary

Surrogate measures of insulin resistance: does one size fit all?
Donald C. Simonson

Reviews

Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery
Deanna M. Arble, Darleen A. Sandoval, Randy J. Seeley

GLUT2, glucose sensing and glucose homeostasis
Bernard Thorens

Mind the gap: connexins and cell–cell communication in the diabetic kidney
Claire E. Hills, Gareth W. Price, Paul E. Squires

Systematic Review/Meta-analysis

Sex-specific differences in diabetes prevention: a systematic review and meta-analysis
Anna Glechner, Jürgen Harreiter, Gerald Gartlehner, Sonja Rohleder, Alexander Kautzky, Jaakko Tuomilehto, Megan Van Noord, Angela Kaminski-Hartenthaler, Alexandra Kautzky-Willer

Articles

Clinical Science and Care

Low-energy diets differing in fibre, red meat and coffee intake equally improve insulin sensitivity in type 2 diabetes: a randomised feasibility trial
Bettina Nowotny, Lejla Zahiragic, Alessandra Bierwagen, Stefan Kabisch, Jan B. Groener, Peter J. Nowotny, Ann Kristin Fleitmann, Christian Herder, Giovanni Pacini, Iris Erlund, Rikard Landberg, Hans-Ulrich Haering, Andreas F. H. Pfeiffer, Peter P. Nawroth, Michael Roden

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Epidemiology

Comparison of HOMA-IR, HOMA-β% and disposition index between US white men and Japanese men in Japan: the ERA JUMP study
Vasudha Ahuja, Takashi Kadowaki, Rhobert W. Evans, Aya Kadota, Tomonori Okamura, Samar R. El Khoudary, Akira Fujiyoshi, Emma J. M. Barinas-Mitchell, Takashi Hisamatsu, Abhishek Vishnu, Katsuyuki Miura, Hiroshi Maegawa, Aiman El-Saed, Atsunori Kashiwagi, Lewis H. Kuller, Hirotsugu Ueshima, Akira Sekikawa, for the ERA JUMP Study Group

Racial and ethnic disparities in extremes of fetal growth after gestational diabetes mellitus
Anny H. Xiang, Mary Helen Black, Bonnie H. Li, Mayra P. Martinez, David A. Sacks, Jean M. Lawrence, Thomas A. Buchanan, Steven J. Jacobsen

Erythrocyte membrane fatty acid fluidity and risk of type 2 diabetes in the EPIC-Potsdam study
Janine Kröger, Simone Jacobs, Eugène H. J. M. Jansen, Andreas Fritsche, Heiner Boeing, Matthias B. Schulze

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Genetics

Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children
María A. Mejía-Benítez, Amélie Bonnefond, Loïc Yengo, Marlène Huyvaert, Aurélie Dechaume, Jesús Peralta-Romero, Miguel Klünder-Klünder, Jaime García Mena, Julia S. El-Sayed Moustafa, Mario Falchi, Miguel Cruz, Philippe Froguel

Effect of zinc supplementation on insulin secretion: interaction between zinc and SLC30A8 genotype in Old Order Amish
Nisa M. Maruthur, Jeanne M. Clark, Mao Fu, W. H. Linda Kao, Alan R. Shuldiner

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Islet Studies

Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice
Laurent Vinet, Smaragda Lamprianou, Andrej Babic, Norbert Lange, Fabrizio Thorel, Pedro Luis Herrera, Xavier Montet, Paolo Meda

Beta cell regeneration after single-round immunological destruction in a mouse model
Jason M. Tonne, Toshie Sakuma, Miguel Munoz-Gomez, Moustafa El Khatib, Michael A. Barry, Yogish C. Kudva, Yasuhiro Ikeda

Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells
Haiqiang Dou, Changhe Wang, Xi Wu, Lijun Yao, Xiaoyu Zhang, Sasa Teng, Huadong Xu, Bin Liu, Qihui Wu, Quanfeng Zhang, Meiqin Hu, Yeshi Wang, Li Wang, Yi Wu, Shujiang Shang, Xinjiang Kang, Lianghong Zheng, Jin Zhang, Matthieu Raoux, Jochen Lang, Qing Li, Jing Su, Xiao Yu, Liangyi Chen, Zhuan Zhou

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Immunology and Transplantation

Single-centre study of 628 adult, primary kidney transplant recipients showing no unfavourable effect of new-onset diabetes after transplant
Jeffrey J. Gaynor, Gaetano Ciancio, Giselle Guerra, Junichiro Sageshima, Lois Hanson, David Roth, Michael J. Goldstein, Linda Chen, Warren Kupin, Adela Mattiazzi, Lissett Tueros, Sandra Flores, Luis J. Barba, Adrian Lopez, Jose Rivas, Phillip Ruiz, Rodrigo Vianna, George W. Burke III

A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models
Pär G. Larsson, Tadepally Lakshmikanth, Olli H. Laitinen, Renata Utorova, Stella Jacobson, Maarit Oikarinen, Erna Domsgen, Minni R. L. Koivunen, Pascal Chaux, Nicolas Devard, Valerie Lecouturier, Jeffrey Almond, Mikael Knip, Heikki Hyöty, Malin Flodström-Tullberg

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Metabolism

Isolated hyperglycaemia does not increase VLDL-triacylglycerol secretion in type 1 diabetic men
Rakel F. Johansen, Esben Søndergaard, Lars Peter Sørensen, Birgitte Nellemann, Jens S. Christiansen, Søren Nielsen

Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes
Jette Bork-Jensen, Camilla Scheele, Daniel V. Christophersen, Emma Nilsson, Martin Friedrichsen, Denise S. Fernandez-Twinn, Louise G. Grunnet, Thomas Litman, Kim Holmstrøm, Birgitte Vind, Kurt Højlund, Henning Beck-Nielsen, Jørgen Wojtaszewski, Susan E. Ozanne, Bente K. Pedersen, Pernille Poulsen, Allan Vaag

Nutritional strategy to prevent fatty liver and insulin resistance independent of obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice
Farnaz Keyhani-Nejad, Martin Irmler, Frank Isken, Eva K. Wirth, Johannes Beckers, Andreas L. Birkenfeld, Andreas F. H. Pfeiffer

Genetic deletion of Wdr13 improves the metabolic phenotype of Leprdb/db mice by modulating AP1 and PPARγ target genes
Vijay P. Singh, Chandrashekaran Gurunathan, Sachin Singh, Bhavtaran Singh, B. Jyothi Lakshmi, Arun P. Mishra, Satish Kumar

daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans
Michael Mendler, Andreas Schlotterer, Youssef Ibrahim, Georgi Kukudov, Thomas Fleming, Angelika Bierhaus, Christin Riedinger, Vedat Schwenger, Stephan Herzig, Markus Hecker, Jens Tyedmers, Peter P. Nawroth, Michael Morcos

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Pathophysiology and Complications

Bone marrow-derived TNF-α causes diabetic neuropathy in mice
Hiroshi Urabe, Tomoya Terashima, Fan Lin, Hideto Kojima, Lawrence Chan

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Research Letter

Progression from single to multiple islet autoantibodies often occurs soon after seroconversion: implications for early screening
Ruth Chmiel, Eleni Z. Giannopoulou, Christiane Winkler, Peter Achenbach, Anette-Gabriele Ziegler, Ezio Bonifacio

Letters

Surrogate measures of insulin sensitivity vs the hyperinsulinaemic–euglycaemic clamp: a meta-analysis. Are there not some surrogate indexes lost in this story?
Jean-Philippe Bastard, Rémi Rabasa-Lhoret, Martine Laville, Emmanuel Disse

Surrogate measures of insulin sensitivity vs the hyperinsulinaemic–euglycaemic clamp: a meta-analysis. Are there not some surrogate indexes lost in this story? Reply to Bastard JP, Rabasa-Lhoret R, Laville M and Disse E [letter]
Julia Otten, Bo Ahrén, Tommy Olsson

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