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Lantus insulin: a possible link with cancer which requires further investigation

Diabetologia currently has a series of four papers and an Editorial in press, all relating to a possible link between insulin glargine (Lantus insulin) and cancer. Advance copies of these papers and relevant patient information are available here and also from the EASD website.

Welcome to Diabetologia

Diabetologia publishes original clinical and experimental research within the field of diabetes. We are interested in papers that convey new information or insight into any aspect of the condition, ranging from basic science to clinical applications. These are judged in terms of their scientific quality, novelty, relevance and interest to our broadly-based readership.

Current issue: July 2009

July 2009 cover


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The cover picture shows a high-magnification double-immunofluorescence micrograph of CD3 T cells (red) in a pancreas-draining lymph node of an insulin-dependent diabetic rat (LEW.1AR1-iddm; an animal model of human type 1 diabetes). The protein content of the anti-inflammatory cytokine IL-4 (green) is shown as an overlay. The density of T cells co-expressing IL-4 (yellow) is increased in animals that are protected against diabetes. In the present issue of Diabetologia (52: 1381–1390) Arndt et al. report that after transfer of CD8 T cells the insulin-dependent diabetic rats are protected against diabetes manifestation, and that the immune cells in the pancreas-draining lymph nodes show a shift to anti-inflammatory cytokines.

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COVER CREDIT: A. JOERNS, INSTITUTE OF CLINICAL BIOCHEMISTRY, HANNOVER MEDICAL SCHOOL, HANNOVER, GERMANY


Editor's choice


Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene–gene interaction
T. Sparsø, N. Grarup, C. Andreasen, A. Albrechtsen, J. Holmkvist, G. Andersen, T. Jørgensen, K. Borch-Johnsen, A. Sandbæk, T. Lauritzen, S. Madsbad, T. Hansen and O. Pedersen

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Inside this issue

Commentaries

Megatrials in type 2 diabetes. From excitement to frustration?
S. Del Prato
DOI 10.1007/s00125-009-1352-5

Translating TCF7L2: from gene to function
E. R. Pearson
DOI 10.1007/s00125-009-1356-1

Reviews

Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA
A. Krook and J. R. Zierath
DOI 10.1007/s00125-009-1330-y

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene
H. Mulder, C. L. F. Nagorny, V. Lyssenko and L. Groop
DOI 10.1007/s00125-009-1359-y

Articles

Clinical Science and Care

Glycaemic impact of patient-led use of sensor-guided pump therapy in type 1 diabetes: a randomised controlled trial
M. A. O’Connell, S. Donath, D. N. O’Neal, P. G. Colman, G. R. Ambler, T. W. Jones, E. A. Davis and F. J. Cameron
DOI 10.1007/s00125-009-1365-0

Masked nocturnal hypertension—a novel marker of risk in type 2 diabetes
M. Wijkman, T. Länne, J. Engvall, T. Lindström, C. J. Östgren and F. H. Nystrom
DOI 10.1007/s00125-009-1369-9

Predictors of depressive symptoms in persons with diabetic peripheral neuropathy: a longitudinal study
L. Vileikyte, M. Peyrot, J. S. Gonzalez, R. R. Rubin, A. P. Garrow, D. Stickings, C. Waterman, J. S. Ulbrecht, P. R. Cavanagh and A. J. M. Boulton
DOI 10.1007/s00125-009-1363-2

Use of cystatin C-based estimations of glomerular filtration rate in patients with type 2 diabetes
Short Communication
R. A. Chudleigh, R. L. Ollerton, G. Dunseath, R. Peter, J. N. Harvey, S. Luzio and D. R. Owens
DOI 10.1007/s00125-009-1379-7

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Epidemiology

Relationship between glycated haemoglobin and microvascular complications: Is there a natural cut-off point for the diagnosis of diabetes?
C. Sabanayagam, G. Liew, E. S. Tai, A. Shankar, S. C. Lim, T. Subramaniam and T. Y. Wong
DOI 10.1007/s00125-009-1360-5

Risk of type 2 diabetes among individuals with high and low glomerular filtration rates
C. Lorenzo, S. D. Nath, A. J. G. Hanley, H. E. Abboud, J. A. L. Gelfond and S. M. Haffner
DOI 10.1007/s00125-009-1361-4

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Genetics

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men
K. Pilgaard, C. B. Jensen, J. H. Schou, V. Lyssenko, L. Wegner, C. Brøns, T. Vilsbøll, T. Hansen, S. Madsbad, J. J. Holst, A. Vølund, P. Poulsen, L. Groop, O. Pedersen and A. A. Vaag
DOI 10.1007/s00125-009-1307-x

Combined analysis of 19 common validated type 2 diabetes susceptibility gene variants shows moderate discriminative value and no evidence of gene–gene interaction
T. Sparsø, N. Grarup, C. Andreasen, A. Albrechtsen, J. Holmkvist, G. Andersen, T. Jørgensen, K. Borch-Johnsen, A. Sandbæk, T. Lauritzen, S. Madsbad, T. Hansen and O. Pedersen
DOI 10.1007/s00125-009-1362-3

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China
Y. Liu, D. Z. Zhou, D. Zhang, Z. Chen, T. Zhao, Z. Zhang, M Ning, X. Hu, Y. F. Yang, Z. F. Zhang, L. Yu, L. He and H. Xu
DOI 10.1007/s00125-009-1375-y

Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population
Short Communication
C. Hu, C. Wang, R. Zhang, X. Ma, J. Wang, J. Lu, W. Qin, Y. Bao, K. Xiang and W. Jia
DOI 10.1007/s00125-009-1335-6

A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS)
S. S. Rich, M. O. Goodarzi, N. D. Palmer, C. D. Langefeld, J. Ziegler, S. M. Haffner, M. Bryer-Ash, J. M. Norris, K. D. Taylor, T. Haritunians, J. I. Rotter, Y.-D. I. Chen, L. E. Wagenknecht, D. W. Bowden and R. N. Bergman
DOI 10.1007/s00125-009-1373-0

Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults
A. Jonsson, F. Renström, V. Lyssenko, E. C. Brito, B. Isomaa, G. Berglund, P. M. Nilsson, L. Groop and P. W. Franks
DOI 10.1007/s00125-009-1355-2

The type 1 diabetes protective HLA DQB1*0602 allele is less frequent in gestational diabetes mellitus
Short Communication
A. Papadopoulou, K. F. Lynch, N. Shaat, A. Nilsson, B. Lernmark, K. Berntorp, S.-A. Ivarsson, C.-D. Agardh, Å. Lernmark and on behalf of the DiPiS Study Group
DOI 10.1007/s00125-009-1351-6

Microarray analysis of multiple candidate genes and associated plasma proteins for nephropathy secondary to type 2 diabetes among Chinese individuals
S. C. Lim, J. J. Liu, H. Q. Low, N. G. Morgenthaler, Y. Li, L. Y. Yeoh, Y. S. Wu, S. K. Goh, C. Y. Chionh, S. H. Tan, Y. C. Kon, P. C. Soon, Y. M. Bee, T. Subramaniam, C. F. Sum and K. S. Chia
DOI 10.1007/s00125-009-1368-x

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Islet Studies

The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro
H. Scholz, T. Lund, M. K. Dahle, J. L. Collins, O. Korsgren, J. E. Wang and A. Foss
DOI 10.1007/s00125-009-1366-z

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Immunology and Transplantation

GAD65 vaccination: 5 years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes
C.-D. Agardh, K. F. Lynch, M. Palmér, K. Link and Å. Lernmark
DOI 10.1007/s00125-009-1371-2

Pancreatic beta cell function persists in many patients with chronic type 1 diabetes, but is not dramatically improved by prolonged immunosuppression and euglycaemia from a beta cell allograft
E. H. Liu, B. J. Digon, B. Hirshberg, R. Chang, B. J. Wood, Z. Neeman, A. Kam, R. A. Wesley, S. M. Polly, R. M. Hofmann, K. I. Rother and D. M. Harlan
DOI 10.1007/s00125-009-1342-7

Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes
T. Arndt, D. Wedekind, H. Weiss, M. Tiedge, S. Lenzen, H.-J. Hedrich and A. Jörns
DOI 10.1007/s00125-009-1348-1

Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells
A. M. Madec, R. Mallone, G. Afonso, E. Abou Mrad, A. Mesnier, A. Eljaafari and C. Thivolet
DOI 10.1007/s00125-009-1374-z

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Metabolism

Are substrate use during exercise and mitochondrial respiratory capacity decreased in arm and leg muscle in type 2 diabetes?
S. Larsen, I. Ara, R. Rabøl, J. L. Andersen, R. Boushel, F. Dela and J. W. Helge
DOI 10.1007/s00125-009-1353-4

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase
V. B. Matthews, M.-B. Åström, M. H. S. Chan, C. R. Bruce, K. S. Krabbe, O. Prelovsek, T. Åkerström, C. Yfanti, C. Broholm, O. H. Mortensen, M. Penkowa, P. Hojman, A. Zankari, M. J. Watt, H. Bruunsgaard, B. K. Pedersen and M. A. Febbraio
DOI 10.1007/s00125-009-1364-1

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Pathophysiology and Complications

Relationship between glyco-oxidation, antioxidant status and microalbuminuria in type 2 diabetic patients
F. Piarulli, G. Sartore, A. Ceriello, E. Ragazzi, R. Reitano, L. Nollino, C. Cosma, D. Fedele and A. Lapolla
DOI 10.1007/s00125-009-1367-y

Associations between autoantibodies against apolipoprotein B-100 peptides and vascular complications in patients with type 2 diabetes
G. N. Fredrikson, D. V. Anand, D. Hopkins, R. Corder, R. Alm, E. Bengtsson, P. K. Shah, A. Lahiri and J. Nilsson
DOI 10.1007/s00125-009-1377-9

Apolipoprotein E deficiency abrogates insulin resistance in a mouse model of type 2 diabetes mellitus
Y. Kawashima, J. Chen, H. Sun, D. Lann, R. J. Hajjar, S. Yakar and D. LeRoith
DOI 10.1007/s00125-009-1378-8

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Research Letters

Development of type 1 diabetes in a patient treated with anti-TNF-α therapy for active rheumatoid arthritis
C. J. Tack, F. S. Kleijwegt, P. L. C. M. Van Riel and B. O. Roep
DOI 10.1007/s00125-009-1381-0

Prevention of diabetes by a hydrolysed casein-based diet in diabetes-prone BioBreeding rats does not involve restoration of the defective natural regulatory T cell function
J. Visser, J. L. Hillebrands, M. Walther Boer, N. A. Bos and J. Rozing
DOI 10.1007/s00125-009-1370-3

Letters

Rosiglitazone: to be or not to be?
A. J. Scheen
DOI 10.1007/s00125-009-1358-z

Causal interpretation requires appropriate study design
P. C. Priest
DOI 10.1007/s00125-009-1346-3

Causal interpretation requires appropriate study design. Reply to Priest PC [letter]
S. J. Richardson, A. Willcox, A. J. Bone, A. K. Foulis and N. G. Morgan
DOI 10.1007/s00125-009-1376-x

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Errata

Accelerated atrophy of lower leg and foot muscles—a follow-up study of long-term diabetic polyneuropathy using magnetic resonance imaging (MRI)
C. S. Andreassen, J. Jakobsen, S. Ringgaard, N. Ejskjaer and H. Andersen
DOI 10.1007/s00125-009-1372-1

n-3 Fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet
O. Kuda, T. Jelenik, Z. Jilkova, P. Flachs, M. Rossmeisl, M. Hensler, L. Kazdova, N. Ogston, M. Baranowski, J. Gorski, P. Janovska, V. Kus, J. Polak, V. Mohamed-Ali, R. Burcelin, S. Cinti, M. Bryhn and J. Kopecky
DOI 10.1007/s00125-009-1388-6

Assessing gene–treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program
P. W. Franks, K. A. Jablonski, L. M. Delahanty, J. B. McAteer, S. E. Kahn, W. C. Knowler, J. C. Florez and for the Diabetes Prevention Program Research Group
DOI 10.1007/s00125-009-1389-5

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