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Welcome to Diabetologia
Diabetologia publishes original clinical and experimental research within the field of diabetes. We are interested in papers that convey new information or insight into any aspect of the condition, ranging from basic science to clinical applications. These are judged in terms of their scientific quality, novelty, relevance and interest to our broadly based readership.
Current issue: August 2010
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The cover picture shows a light microscopic image of a transverse section of a haematoxylin-eosin-stained human saphenous vein that has been organ-cultured for 14 days in medium supplemented with insulin. Significant neointima formation is visible in the lumen of the cultured vessel. This arises from increased vascular smooth muscle cell migration and proliferation, ultimately leading to vessel occlusion. In the present issue of Diabetologia (53:1761-1771), Mughal et al. report that co-supplementation of insulin-treated vein cultures with C-peptide, a cleavage product of proinsulin, abrogates this perceived detrimental effect of insulin. These findings suggest that co-supplementing insulin therapy with C-peptide in patients with diabetes may be beneficial in ameliorating some of the macrovascular complications of diabetes.
COVER CREDIT: J. Kaye, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, UK
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Editor's choice
Glucose-lowering agents and cancer mortality rates in type 2 diabetes: assessing effects of time-varying exposure
S. L. Bowker, Y. Yasui, P. Veugelers and J. A. Johnson
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Inside this issue
Commentaries
Cancer and diabetes: are we ready for prime time?
U. Smith and E. A. M. Gale
DOI 10.1007/s00125-010-1815-8
Vitamin D and diabetes: the devil is in the D-tails
C. Mathieu
DOI 10.1007/s00125-010-1791-z
Zinc, zinc transporters and diabetes
J. Rungby
DOI 10.1007/s00125-010-1793-x
Review
The case for hypoglycaemia as a proarrhythmic event: basic and clinical evidence
C. Nordin
DOI 10.1007/s00125-010-1752-6
Personal View
Is there an impatience genotype leading to non-adherence to long-term therapies?
G. Reach
DOI 10.1007/s00125-010-1755-3
Articles
- Clinical Science and Care
- Epidemiology
- Genetics
- Islet Studies
- Immunology and Transplantation
- Metabolism
- Pathophysiology and Complications
Clinical Science and Care
Effects of the peroxisome proliferator-activated receptor (PPAR)-γ agonist pioglitazone on renal and hormonal responses to salt in diabetic and hypertensive individuals
A. Zanchi, M. Maillard, F. R. Jornayvaz, M. Vinciguerra, P. Deleaval, J. Nussberger, M. Burnier and A. Pechere-Bertschi
DOI 10.1007/s00125-010-1756-2
Optimal antiproteinuric dose of aliskiren in type 2 diabetes mellitus: a randomised crossover trial
Short Communication
F. Persson, P. Rossing, H. Reinhard, T. Juhl, C. D. A. Stehouwer, C. Schalkwijk, A. H. J. Danser, F. Boomsma, E. Frandsen and H.-H. Parving
DOI 10.1007/s00125-010-1789-6
Cardiovascular disease risk factors, depression symptoms and antidepressant medicine use in the Look AHEAD (Action for Health in Diabetes) clinical trial of weight loss in diabetes
R. R. Rubin, S. A. Gaussoin, M. Peyrot, V. DiLillo, K. Miller, T. A. Wadden, D. S. West, R. R. Wing, W. C. Knowler and for the Look AHEAD Research Group
DOI 10.1007/s00125-010-1765-1
Coping style and depression influence the healing of diabetic foot ulcers: observational and mechanistic evidence
K. Vedhara, J. N. V. Miles, M. A. Wetherell, K. Dawe, A. Searle, D. Tallon, N. Cullum, A. Day, C. Dayan, N. Drake, P. Price, J. Tarlton, J. Weinman and R. Campbell
DOI 10.1007/s00125-010-1743-7
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Epidemiology
Maternal intake of vitamin D during pregnancy and risk of advanced beta cell autoimmunity and type 1 diabetes in offspring
L. Marjamäki, S. Niinistö, M. G. Kenward, L. Uusitalo, U. Uusitalo, M.-L. Ovaskainen, C. Kronberg-Kippilä, O. Simell, R. Veijola, J. Ilonen, M. Knip and S. M. Virtanen
DOI 10.1007/s00125-010-1734-8
Real-life glycaemic profiles in non-diabetic individuals with low fasting glucose and normal HbA1c: the A1C-Derived Average Glucose (ADAG) study
Short Communication
R. Borg, J. C. Kuenen, B. Carstensen, H. Zheng, D. M. Nathan, R. J. Heine, J. Nerup, K. Borch-Johnsen, D. R. Witte and on behalf of the ADAG Study Group
DOI 10.1007/s00125-010-1741-9
Changes in short- and long-term cardiovascular risk of incident diabetes and incident myocardial infarction—a nationwide study
M. L. Norgaard, S. S. Andersen, T. K. Schramm, F. Folke, C. H. Jørgensen, M. L. Hansen, C. Andersson, D. M. Bretler, A. Vaag, L. Køber, C. Torp-Pedersen and G. H. Gislason
DOI 10.1007/s00125-010-1783-z
Physical activity, obesity and cardiometabolic risk factors in 9- to 10-year-old UK children of white European, South Asian and black African-Caribbean origin: the Child Heart And health Study in England (CHASE)
C. G. Owen, C. M. Nightingale, A. R. Rudnicka, N. Sattar, D. G. Cook, U. Ekelund and P. H. Whincup
DOI 10.1007/s00125-010-1781-1
Glucose-lowering agents and cancer mortality rates in type 2 diabetes: assessing effects of time-varying exposure
S. L. Bowker, Y. Yasui, P. Veugelers and J. A. Johnson
DOI 10.1007/s00125-010-1750-8
The relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes
R. Klein, M. D. Knudtson, B. E. K. Klein, B. Zinman, R. Gardiner, S. Suissa, A. R. Sinaiko, S. M. Donnelly, P. Goodyer, T. Strand and M. Mauer
DOI 10.1007/s00125-010-1763-3
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Genetics
Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people
T. W. Boesgaard, N. Grarup, T. Jørgensen, K. Borch-Johnsen, Meta-Analysis of Glucose and Insulin-Related Trait Consortium (MAGIC), T. Hansen and O. Pedersen
DOI 10.1007/s00125-010-1753-5
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Islet Studies
Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion
N. Wijesekara, F. F. Dai, A. B. Hardy, P. R. Giglou, A. Bhattacharjee, V. Koshkin, F. Chimienti, H. Y. Gaisano, G. A. Rutter and M. B. Wheeler
DOI 10.1007/s00125-010-1733-9
In vivo non-viral gene delivery of human vascular endothelial growth factor improves revascularisation and restoration of euglycaemia after human islet transplantation into mouse liver
M. Shimoda, S. Chen, H. Noguchi, S. Matsumoto and P. A. Grayburn
DOI 10.1007/s00125-010-1745-5
Reciprocal modulation of adult beta cell maturity by activin A and follistatin
M. Szabat, J. D. Johnson and J. M. Piret
DOI 10.1007/s00125-010-1758-0
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Immunology and Transplantation
Human islet cell implants in a nude rat model of diabetes survive better in omentum than in liver with a positive influence of beta cell number and purity
D. Jacobs-Tulleneers-Thevissen, K. Bartholomeus, K. Suenens, I. Vermeulen, Z. Ling, K. H. Hellemans, P. In’t Veld, M. Pipeleers-Marichal and D. Pipeleers
DOI 10.1007/s00125-010-1721-0
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Metabolism
A family history of type 2 diabetes increases risk factors associated with overfeeding
D. Samocha-Bonet, L. V. Campbell, A. Viardot, J. Freund, C. S. Tam, J. R. Greenfield and L. K. Heilbronn
DOI 10.1007/s00125-010-1768-y
A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)–Botnia study
Short Communication
B. Isomaa, B. Forsén, K. Lahti, N. Holmström, J. Wadén, O. Matintupa, P. Almgren, J. G. Eriksson, V. Lyssenko, M.-R. Taskinen, T. Tuomi and L. C. Groop
DOI 10.1007/s00125-010-1776-y
Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals
E. Phielix, R. Meex, E. Moonen-Kornips, M. K. C. Hesselink and P. Schrauwen
DOI 10.1007/s00125-010-1764-2
Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide
M. Whiteman, K. M. Gooding, J. L. Whatmore, C. I. Ball, D. Mawson, K. Skinner, J. E. Tooke and A. C. Shore
DOI 10.1007/s00125-010-1761-5
Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice
Short Communication
X. Rong, Y. Li, K. Ebihara, M. Zhao, J. Naowaboot, T. Kusakabe, K. Kuwahara, M. Murray and K. Nakao
DOI 10.1007/s00125-010-1744-6
IL-6 deficiency in mice neither impairs induction of metabolic genes in the liver nor affects blood glucose levels during fasting and moderately intense exercise
L. Fritsche, M. Hoene, R. Lehmann, H. Ellingsgaard, A. M. Hennige, A. K. Pohl, H. U. Häring, E. D. Schleicher and C. Weigert
DOI 10.1007/s00125-010-1754-4
Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling
L. Sciacca, M. F. Cassarino, M. Genua, G. Pandini, R. Le Moli, S. Squatrito and R. Vigneri
DOI 10.1007/s00125-010-1760-6
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Pathophysiology and Complications
Bone status in adolescents with type 1 diabetes
A. P. Chobot, A. Haffke, J. Polanska, Z. P. Halaba, G. Deja, P. Jarosz-Chobot and W. Pluskiewicz
DOI 10.1007/s00125-010-1782-0
Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein
R. S. Mughal, J. L. Scragg, P. Lister, P. Warburton, K. Riches, D. J. O’Regan, S. G. Ball, N. A. Turner and K. E. Porter
DOI 10.1007/s00125-010-1736-6
Lymphocytes promote albuminuria, but not renal dysfunction or histological damage in a mouse model of diabetic renal injury
A. K. H. Lim, F. Y. Ma, D. J. Nikolic-Paterson, A. R. Kitching, M. C. Thomas and G. H. Tesch
DOI 10.1007/s00125-010-1757-1
Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes
A. Makino, B. T. Scott and W. H. Dillmann
DOI 10.1007/s00125-010-1770-4
Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet
J. A. Ehses, D. T. Meier, S. Wueest, J. Rytka, S. Boller, P. Y. Wielinga, A. Schraenen, K. Lemaire, S. Debray, L. Van Lommel, J. A. Pospisilik, O. Tschopp, S. M. Schultze, U. Malipiero, H. Esterbauer, H. Ellingsgaard, S. Rütti, F. C. Schuit, T. A. Lutz, M. Böni-Schnetzler, D. Konrad and Marc Y. Donath
DOI 10.1007/s00125-010-1747-3
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Letters
Obstructive sleep apnoea and the orexigenic pathway in type 2 diabetes
M. K. S. Leow
DOI 10.1007/s00125-010-1778-9
Prevention strategies for type 2 diabetes should be based on evidence-based medical nutrition data
M. Uusitupa, J. Lindström and J. Tuomilehto
DOI 10.1007/s00125-010-1779-8
Errata
Erratum to: Dimorphic histopathology of long-standing childhood-onset diabetes
R. Gianani, M. Campbell-Thompson, S. A. Sarkar, C. Wasserfall, A. Pugliese, J. M. Solis, S. C. Kent, B. J. Hering, E. West, A. Steck, S. Bonner-Weir, M. A. Atkinson, K. Coppieters, M. von Herrath and G. S. Eisenbarth
DOI 10.1007/s00125-010-1769-x
Erratum to: Is the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis
G. Schernthaner, A. H. Barnett, D. J. Betteridge, R. Carmena, A. Ceriello, B. Charbonnel, M. Hanefeld, R. Lehmann, M. T. Malecki, R. Nesto, V. Pirags, A. Scheen, J. Seufert, Å. Sjöholm, A. Tsatsoulis and R. DeFronzo
DOI 10.1007/s00125-010-1797-6