Diabetologia

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Welcome to Diabetologia

Diabetologia publishes original clinical and experimental research within the field of diabetes. We are interested in papers that convey new information or insight into any aspect of the condition, ranging from basic science to clinical applications. These are judged in terms of their scientific quality, novelty, relevance and interest to our broadly-based readership.

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The cover picture shows a coloured TEM of a rubella virus. Rubella is an RNA virus with a lipid envelope that produces a ring or 'toga' effect under the electron microscope. The congenital rubella syndrome provides the only unequivocal evidence that a virus can cause diabetes, but its association with type 1 diabetes is more complex than previously appreciated (see Gale 51:1559-1566).

Cover credit: DR RAY CLARK & MERVYN GOFF/SCIENCE PHOTO LIBRARY

Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes: experience of the PedPump Study in 17 countries

by T. Danne, T. Battelino, P. Jarosz-Chobot, O. Kordonouri, E. Pánkowska, J. Ludvigsson, E. Schober, E. Kaprio, T. Saukkonen, M. Nicolino, N. Tubiana-Rufi, C. Klinkert, H. Haberland, A. Vazeou, L. Madacsy, D. Zangen, V. Cherubini, I. Rabbone, S. Toni, C. de Beaufort, W. Bakker-van Waarde, N. van den Berg, I. Volkov, R. Barrio, R. Hanas, U. Zumsteg, B. Kuhlmann, C. Aebi, U. Schumacher, S. Gschwend, P. Hindmarsh, M. Torres, N. Shehadeh, M. Phillip and the PedPump Study Group

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Editorial

Congenital rubella: citation virus or viral cause of type 1 diabetes?
E. A. M. Gale
DOI 10.1007/s00125-008-1099-4

Commentaries

Is a nutritional therapeutic approach unsuitable for metabolically healthy but obese women?
G. Perseghin
DOI 10.1007/s00125-008-1077-x

Is blockade of vascular endothelial growth factor beneficial for all types of diabetic retinopathy?
D. N. Sang and P. A. D’Amore
DOI 10.1007/s00125-008-1078-9

Reviews

Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy
R. Simó and C. Hernández
DOI 10.1007/s00125-008-0989-9

Non-invasive cardiac imaging techniques and vascular tools for the assessment of cardiovascular disease in type 2 diabetes mellitus
R. Djaberi, E. D. Beishuizen, A. M. Pereira, T. J. Rabelink, J. W. Smit, J. T. Tamsma, M. V. Huisman and J. W. Jukema
DOI 10.1007/s00125-008-1062-4

Articles

• Clinical Science and Care
• Epidemiology
• Genetics
• Islet Studies
• Metabolism
• Pathophysiology and Complications

Clinical Science and Care

Establishing glycaemic control with continuous subcutaneous insulin infusion in children and adolescents with type 1 diabetes: experience of the PedPump Study in 17 countries
T. Danne, T. Battelino, P. Jarosz-Chobot, O. Kordonouri, E. Pánkowska, J. Ludvigsson, E. Schober, E. Kaprio, T. Saukkonen, M. Nicolino, N. Tubiana-Rufi, C. Klinkert, H. Haberland, A. Vazeou, L. Madacsy, D. Zangen, V. Cherubini, I. Rabbone, S. Toni, C. de Beaufort, W. Bakker-van Waarde, N. van den Berg, I. Volkov, R. Barrio, R. Hanas, U. Zumsteg, B. Kuhlmann, C. Aebi, U. Schumacher, S. Gschwend, P. Hindmarsh, M. Torres, N. Shehadeh, M. Phillip and and the PedPump Study Group
DOI 10.1007/s00125-008-1072-2

A novel insulin formulation with a more rapid onset of action
Short Communication
S. Steiner, M. Hompesch, R. Pohl, P. Simms, F. Flacke, T. Mohr, A. Pfützner and L. Heinemann
DOI 10.1007/s00125-008-1095-8

Low glycaemic index diet and disposition index in type 2 diabetes (the Canadian trial of Carbohydrates in Diabetes): a randomised controlled trial
T. M. S. Wolever, C. Mehling, J.-L. Chiasson, R. G. Josse, L. A. Leiter, P. Maheux, R. Rabasa-Lhoret, N. W. Rodger and E. A. Ryan
DOI 10.1007/s00125-008-1093-x

A modified Mediterranean diet is associated with the greatest reduction in alanine aminotransferase levels in obese type 2 diabetes patients: results of a quasi-randomised controlled trial
A. Fraser, R. Abel, D. A. Lawlor, D. Fraser and A. Elhayany
DOI 10.1007/s00125-008-1049-1

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Epidemiology

Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes
H. Elding Larsson, G. Hansson, A. Carlsson, E. Cederwall, B. Jonsson, B. Jönsson, K. Larsson, K. Lynch, J. Neiderud, Å. Lernmark, S.-A. Ivarsson and for the DiPiS Study Group
DOI 10.1007/s00125-008-1074-0

Alcohol consumption and risk of microvascular complications in type 1 diabetes patients: the EURODIAB Prospective Complications Study
J. W. J. Beulens, J. S. Kruidhof, D. E. Grobbee, N. Chaturvedi, J. H. Fuller and S. S. Soedamah-Muthu
DOI 10.1007/s00125-008-1091-z

Risk of myocardial infarction in men and women with type 2 diabetes in the UK: a cohort study using the General Practice Research Database
H. E. Mulnier, H. E. Seaman, V. S. Raleigh, S. S. Soedamah-Muthu, H. M. Colhoun, R. A. Lawrenson and C. S. de Vries
DOI 10.1007/s00125-008-1076-y

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Genetics

Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation
T. Sparsø, G. Andersen, A. Albrechtsen, T. Jørgensen, K. Borch-Johnsen, A. Sandbæk, T. Lauritzen, J. Wasson, M. A. Permutt, B. Glaser, S. Madsbad, O. Pedersen and T. Hansen
DOI 10.1007/s00125-008-1064-2

Study of the association between the CAPSL-IL7R locus and type 1 diabetes
J. L. Santiago, B. Z. Alizadeh, A. Martínez, L. Espino, H. de la Calle, M. Fernández-Arquero, M. A. Figueredo, E. G. de la Concha, B. O. Roep, B. P. C. Koeleman and E. Urcelay
DOI 10.1007/s00125-008-1070-4

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps
Short Communication
M. J. Groenewoud, J. M. Dekker, A. Fritsche, E. Reiling, G. Nijpels, R. J. Heine, J. A. Maassen, F. Machicao, S. A. Schäfer, H. U. Häring, L. M. ’t Hart and T. W. van Haeften
DOI 10.1007/s00125-008-1083-z

Retinal and renal complications in patients with a mutation of mitochondrial DNA at position 3,243 (maternally inherited diabetes and deafness). A case–control study
P. Massin, D. Dubois-Laforgue, T. Meas, M. Laloi-Michelin, H. Gin, B. Bauduceau, C. Bellanné-Chantelot, E. Bertin, J.-F. Blickle, B. Bouhanick, J. Cahen-Varsaux, S. Casanova, G. Charpentier, P. Chedin, O. Dupuy, A. Grimaldi, B. Guerci, E. Kaloustian, A. Lecleire-Collet, F. Lorenzini, A. Murat, H. Narbonne, F. Olivier, V. Paquis-Flucklinger, M. Virally, M. Vincenot, B. Vialettes, J. Timsit, P. J. Guillausseau and for the GEDIAM (Mitochondrial Diabetes French Study Group)
DOI 10.1007/s00125-008-1073-1

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Islet Studies

Differentiation of mouse nuclear transfer embryonic stem cells into functional pancreatic beta cells
W. Jiang, Z. Bai, D. Zhang, Y. Shi, J. Yong, S. Chen, M. Ding and H. Deng
DOI 10.1007/s00125-008-1065-1

Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis
H. F. Irving-Rodgers, A. F. Ziolkowski, C. R. Parish, Y. Sado, Y. Ninomiya, C. J. Simeonovic and R. J. Rodgers
DOI 10.1007/s00125-008-1085-x

Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon
Short Communication
S. C. Collins, A. Salehi, L. Eliasson, C. S. Olofsson and P. Rorsman
DOI 10.1007/s00125-008-1082-0

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Metabolism

Reduced tricarboxylic acid cycle flux in type 2 diabetes mellitus?
Short Communication
P. Schrauwen and M. K. C. Hesselink
DOI 10.1007/s00125-008-1069-x

Increased fat:carbohydrate oxidation ratio in Il1ra^−/− mice on a high-fat diet is associated with increased sympathetic tone
D. Chida, O. Hashimoto, M. Kuwahara, H. Sagara, T. Osaka, H. Tsubone and Y. Iwakura
DOI 10.1007/s00125-008-1075-z

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Pathophysiology and Complications

The development of microalbuminuria is associated with raised longitudinal adiponectin levels in female but not male adolescent patients with type 1 diabetes
R. Amin, J. Frystyk, K. Ong, R. N. Dalton, A. Flyvbjerg and D. B. Dunger
DOI 10.1007/s00125-008-1081-1

Performance of the revised ‘175’ Modification of Diet in Renal Disease equation in patients with type 2 diabetes
Short Communication
R. A. Chudleigh, R. L. Ollerton, G. Dunseath, R. Peter, J. N. Harvey, S. Luzio and D. R. Owens
DOI 10.1007/s00125-008-1086-9

Ethnic differences in retinal microvascular structure
Short Communication
T. Tillin, R. M. Evans, N. W. Witt, P. S. Sharp, P. M. McKeigue, N. Chaturvedi and A. D. Hughes
DOI 10.1007/s00125-008-1096-7

Evaluation of N^ε-(3-formyl-3,4-dehydropiperidino)lysine as a novel biomarker for the severity of diabetic retinopathy
X. Zhang, Y. Lai, D. R. McCance, K. Uchida, D. M. McDonald, T. A. Gardiner, A. W. Stitt and T. M. Curtis
DOI 10.1007/s00125-008-1071-3

The HMG-CoA reductase inhibitor rosuvastatin and the angiotensin receptor antagonist candesartan attenuate atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes via effects on advanced glycation, oxidative stress and inflammation
A. C. Calkin, S. Giunti, K. J. Sheehy, C. Chew, V. Boolell, Y. S. Rajaram, M. E. Cooper and K. A. Jandeleit-Dahm
DOI 10.1007/s00125-008-1060-6

A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-β activation in the kidneys of rats used as a model of diabetes
D. Gong, J. Lu, X. Chen, S. Reddy, D. J. Crossman, S. Glyn-Jones, Y.-S. Choong, J. Kennedy, B. Barry, S. Zhang, Y.-K. Chan, K. Ruggiero, A. R. J. Phillips and G. J. S. Cooper
DOI 10.1007/s00125-008-1088-7

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Research Letter

Metabolically healthy but obese women: effect of an energy-restricted diet
A. D. Karelis, V. Messier, M. Brochu and R. Rabasa-Lhoret
DOI 10.1007/s00125-008-1038-4

Letter

Resistance exercise and control of cerebral blood flow in type 2 diabetes
Y. S. Kim, N. H. Secher and J. J. van Lieshout
DOI 10.1007/s00125-008-1068-y

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