Diabetologia

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
by M. Cnop, S. J. Hughes, M. Igoillo-Esteve, M. B. Hoppa, F. Sayyed, L. van de Laar, J. H. Gunter, E. J. P. de Koning, G. V. Walls, D. W. G. Gray, P. R. V. Johnson, B. C. Hansen, J. F. Morris, M. Pipeleers-Marichal, I. Cnop and A. Clark

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Commentaries

Adipose tissue inflammation: are small or large fat cells to blame?
H. Hauner
DOI 10.1007/s00125-009-1605-3

Genetics of serum resistin: a paradigm of population-specific regulation?
C. Menzaghi and V. Trischitta
DOI 10.1007/s00125-009-1589-z

For Debate

Mitogenic action of insulin: friend, foe or ‘frenemy’?
B. Draznin
DOI 10.1007/s00125-009-1558-6

Articles

• Epidemiology
• Genetics
• Islet Studies
• Immunology and Transplantation
• Metabolism
• Pathophysiology and Complications

Epidemiology

Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population
H. Asano, H. Izawa, K. Nagata, M. Nakatochi, M. Kobayashi, A. Hirashiki, S. Shintani, T. Nishizawa, D. Tanimura, K. Naruse, T. Matsubara, T. Murohara and M. Yokota
DOI 10.1007/s00125-009-1517-2

Risk factors for incident type 2 diabetes in individuals with a BMI of <27 kg/m²: the role of γ-glutamyltransferase. Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
A. Gautier, B. Balkau, C. Lange, J. Tichet, F. Bonnet and for the DESIR Study Group
DOI 10.1007/s00125-009-1602-6

Progression to microalbuminuria in type 1 diabetes: development and validation of a prediction rule
Y. Vergouwe, S. S. Soedamah-Muthu, J. Zgibor, N. Chaturvedi, C. Forsblom, J. K. Snell-Bergeon, D. M. Maahs, P.-H. Groop, M. Rewers, T. J. Orchard, J. H. Fuller and K. G. M. Moons
DOI 10.1007/s00125-009-1585-3

Lipid and inflammatory biomarkers and kidney function decline in type 2 diabetes
J. Lin, F. B. Hu, C. Mantzoros and G. C. Curhan
DOI 10.1007/s00125-009-1597-z

Low adiponectin concentration during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia
R. Retnakaran, Y. Qi, P. W. Connelly, M. Sermer, A. J. Hanley and B. Zinman
DOI 10.1007/s00125-009-1600-8

Reduced plasma levels of glucagon-like peptide-1 in elderly men are associated with impaired glucose tolerance but not with coronary heart disease
Short Communication
D. Nathanson, B. Zethelius, C. Berne, J. J. Holst, Å. Sjöholm and T. Nyström
DOI 10.1007/s00125-009-1596-0

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Genetics

Candidate loci for insulin sensitivity and disposition index from a genome-wide association analysis of Hispanic participants in the Insulin Resistance Atherosclerosis (IRAS) Family Study
N. D. Palmer, C. D. Langefeld, J. T. Ziegler, F. Hsu, S. M. Haffner, T. Fingerlin, J. M. Norris, Y. I. Chen, S. S. Rich, T. Haritunians, K. D. Taylor, R. N. Bergman, J. I. Rotter and D. W. Bowden
DOI 10.1007/s00125-009-1586-2

Association of genetic variants of NOS1AP with type 2 diabetes in a Chinese population
C. Hu, C. Wang, R. Zhang, M. C. Ng, Y. Bao, C. Wang, W. Y. So, R. C. Ma, X. Ma, J. C. Chan, K. Xiang and W. Jia
DOI 10.1007/s00125-009-1594-2

Common variants at the GCK, GCKR, G6PC2–ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations
F. Takeuchi, T. Katsuya, S. Chakrewarthy, K. Yamamoto, A. Fujioka, M. Serizawa, T. Fujisawa, E. Nakashima, K. Ohnaka, H. Ikegami, T. Sugiyama, T. Nabika, A. Kasturiratne, S. Yamaguchi, S. Kono, R. Takayanagi, Y. Yamori, S. Kobayashi, T. Ogihara, A. de Silva, R. Wickremasinghe and N. Kato
DOI 10.1007/s00125-009-1595-1

Diet-induced gene expression of isolated pancreatic islets from a polygenic mouse model of the metabolic syndrome
T. Dreja, Z. Jovanovic, A. Rasche, R. Kluge, R. Herwig, Y. C. L. Tung, H. G. Joost, G. S. H. Yeo and H. Al-Hasani
DOI 10.1007/s00125-009-1576-4

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Islet Studies

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
M. Cnop, S. J. Hughes, M. Igoillo-Esteve, M. B. Hoppa, F. Sayyed, L. van de Laar, J. H. Gunter, E. J. P. de Koning, G. V. Walls, D. W. G. Gray, P. R. V. Johnson, B. C. Hansen, J. F. Morris, M. Pipeleers-Marichal, I. Cnop and A. Clark
DOI 10.1007/s00125-009-1562-x

Peroxisome proliferator-activated receptor α (PPARα) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism
F. Frigerio, T. Brun, C. Bartley, A. Usardi, D. Bosco, K. Ravnskjær, S. Mandrup and P. Maechler
DOI 10.1007/s00125-009-1590-6

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Immunology and Transplantation

A case of recurrent type 1 diabetes mellitus with insulitis of transplanted pancreas in simultaneous pancreas–kidney transplantation from cardiac death donor
Short Communication
M. Ishida-Oku, M. Iwase, A. Sugitani, K. Masutani, H. Kitada, M. Tanaka and M. Iida
DOI 10.1007/s00125-009-1593-3

Enhanced trafficking to the pancreatic lymph nodes and auto-antigen presentation capacity distinguishes peritoneal B lymphocytes in non-obese diabetic mice
C. Alam, S. Valkonen, S. Ohls, K. Törnqvist and A. Hänninen
DOI 10.1007/s00125-009-1599-x

Targeting of IL-2 receptor with a caspase fusion protein disrupts autoimmunity in prediabetic and diabetic NOD mice
S. Yarkoni, A. Kaminitz, Y. Sagiv and N. Askenasy
DOI 10.1007/s00125-009-1604-4

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Metabolism

Inflammation in subcutaneous adipose tissue: relationship to adipose cell size
T. McLaughlin, A. Deng, G. Yee, C. Lamendola, G. Reaven, P. S. Tsao, S. W. Cushman and A. Sherman
DOI 10.1007/s00125-009-1496-3

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Pathophysiology and Complications

Impaired wound healing in mouse models of diabetes is mediated by TNF-α dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1)
M. F. Siqueira, J. Li, L. Chehab, T. Desta, T. Chino, N. Krothpali, Y. Behl, M. Alikhani, J. Yang, C. Braasch and D. T. Graves
DOI 10.1007/s00125-009-1529-y

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Letters

The economic costs of diabetes in developing countries: some concerns and recommendations
A. K. Khuwaja, L. A. Khowaja and P. Cosgrove
DOI 10.1007/s00125-009-1581-7

The economic costs of diabetes in Iran: some concerns and recommendations. Reply to Khuwaja AK, Khowaja LA, Cosgrove P [letter]
A. Esteghamati, O. Khalilzadeh and M. Abbasi
DOI 10.1007/s00125-009-1601-7

Visceral adiposity would be expected to predict incident diabetes better in women than men
C. M. Schooling, C. Q. Jiang, W. S. Zhang, T. H. Lam, K. K. Cheng and G. M. Leung
DOI 10.1007/s00125-009-1613-3

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Errata

Erratum to: Neural crest stem cells increase beta cell proliferation and improve islet function in co-transplanted murine pancreatic islets
J. Olerud, N. Kanaykina, S. Vasylovska, D. King, M. Sandberg, L. Jansson and E. N. Kozlova
DOI 10.1007/s00125-009-1607-1

Erratum to: Determinants of urinary albumin excretion within the normal range in patients with type 2 diabetes: the Randomised Olmesartan and Diabetes Microalbuminuria Prevention (ROADMAP) study
E. Ritz, G. C. Viberti, L. M. Ruilope, A. J. Rabelink, J. L. Izzo, S. Katayama, S. Ito, A. Mimran, J. Menne, L. C. Rump, A. Januszewicz and H. Haller
DOI 10.1007/s00125-009-1623-1

Erratum to: Reduced AMP-activated protein kinase activity in mouse skeletal muscle does not exacerbate the development of insulin resistance with obesity
S. Beck Jørgensen, H. M. O’Neill, K. Hewitt, B. E. Kemp and G. R. Steinberg
DOI 10.1007/s00125-009-1583-5

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