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Welcome to Diabetologia

Diabetologia publishes original clinical and experimental research within the field of diabetes. We are interested in papers that convey new information or insight into any aspect of the condition, ranging from basic science to clinical applications. These are judged in terms of their scientific quality, novelty, relevance and interest to our broadly based readership.

In the News

Study shows children who have had enterovirus infection are around 50% more likely to have type 1 diabetes

Download this new research by Dr Tsai Chung-Li, China Medical University, Taiwan, and colleagues.
For further information contact Dr Chung-Li (cli@mail.cmu.edu.tw).


(posted online 22.01 h BST Friday 17th October 2014)

Women who eat fried food regularly before conceiving are at increased risk of developing gestational diabetes during pregnancy

Download this new research by Drs Cuilin Zhang and Wei Bao from the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the National Institutes of Health, USA, and colleagues.
For further information contact Dr Cuilin Zhang (zhangcu@mail.nih.gov).


(posted online 22.01 h BST Wednesday 8th October 2014)


Association of physical activity with diabetes is weakest among women at high genetic risk

Download this new research by Dr Yann Klimentidis, Assistant Professor at the University of Arizona, Mel and Enid Zuckerman College of Public Health, and colleagues.
For further information contact Dr Yann Klimentidis (yann@email.arizona.edu).


(posted online 22.01 h BST Monday 29th September 2014)

Current issue: November 2014

November 2014 cover

Click here to view this month's contents

The cover image shows a 16-week-old fetus. In the present issue of Diabetologia Holder et al report the potential consequences of exposure to gestational diabetes mellitus (GDM) in utero with regard to beta cell function of the offspring. During adolescence, obesity-associated insulin resistance reveals the impaired ability of beta cells of such offspring to appropriately compensate by increasing insulin secretion. Obese adolescent offspring of mothers who had GDM show increased rates of early altered glucose metabolism.

Cover credit: TISSUEPIX/SCIENCE PHOTO LIBRARY

Download the high resolution cover image

Up front

Juleen Zierath

Competition for publication in Diabetologia is greater than ever, and less than 20% of papers are accepted. Of all the high-quality papers that appear in this month's issue I want to share with you five articles that I find to be of particular interest. These will be featured 'up front' in the print issue and here on our website. Juleen R. Zierath, Editor


Observational studies of the association between glucose-lowering medications and cardiovascular outcomes: addressing methodological limitations
by Elisabetta Patorno, Amanda R. Patrick, Elizabeth M. Garry, Sebastian Schneeweiss, Victoria G. Gillet, Dorothee B. Bartels, Elvira Masso-Gonzalez, John D. Seeger

Observational research plays an increasingly important role in the evaluation of the clinical effects of diabetes treatment on cardiovascular disease. However, many observational studies are based on designs or analyses that inadequately address the methodological challenges involved. In this issue, Patorno et al present a critical review of the recent observational literature on the association between glucose-lowering medications and cardiovascular outcomes and discuss methodological issues. Furthermore, they explain how most of the identified challenges may be suitably addressed through the application of appropriate methods. Greater attention to the principles described in this review may serve to address many recurrent methodological issues and reduce the potential for spurious findings in the observational literature on the cardiovascular effects of glucose-lowering treatments. [Text supplied by the authors.]

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Prediabetes and the risk of cancer: a meta-analysis
by Yi Huang, Xiaoyan Cai, Miaozhen Qiu, Peisong Chen, Hongfeng Tang, Yunzhao Hu, Yuli Huang

Prediabetes is a general term used to refer to an intermediate stage between normoglycaemia and overt diabetes mellitus and includes individuals with impaired glucose tolerance (IGT), impaired fasting glucose (IFG) or a combination of the two. Although epidemiological studies have reported that diabetes increases the incidence of cancer, results to date from prospective cohort studies investigating the link between prediabetes and risk of cancer are controversial. In this issue, Huang et al present the results of a meta-analysis comprising 16 studies and 891,426 participants from various regions of the world. They report that prediabetes increases the risk of cancer by 15%, with differing risks depending on the type of cancer. The risk was particularly increased for liver cancer and stomach or colorectal cancer. These findings have important clinical and public health implications. Considering the high prevalence of prediabetes and striking association with cancer, successful intervention in this large population could have a major public health impact. [Text supplied by the authors.]

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Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
by Michael C. d'Emden, Alicia J. Jenkins, Liping Li, Diana Zannino, Kristy P. Mann, James D. Best, Bronwyn G. A. Stuckey, Kris Park, Juha Saltevo, Anthony C. Keech, on behalf of the FIELD Study Investigators

The Action to Control Cardiovascular Risk in Diabetes (ACCORD) Lipid study suggested a possible adverse effect of fibric acid derivatives in women taking statins. In this issue, d'Emden et al report results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study, the largest study to date to assess the management of dyslipidaemia in type 2 diabetes, further evaluating the role of fenofibrate in diabetic women. Participants, who were not on statin therapy at randomisation, received fenofibrate or placebo. Women on fenofibrate had greater reductions in total cholesterol and LDL-cholesterol than men in the treatment group, independent of whether they had started statin therapy, and had significant reductions in cardiovascular outcomes compared with women on placebo. There was a consistent trend towards greater reductions in cardiovascular endpoints compared with men on fenofibrate. The study supports a role for fenofibrate therapy in women with dyslipidaemia on statin therapy. [Text supplied by the authors.]

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Predicting major outcomes in type 1 diabetes: a model development and validation study
by Sabita S. Soedamah-Muthu, Yvonne Vergouwe, Tina Costacou, Rachel G. Miller, Janice Zgibor, Nish Chaturvedi, Janet K. Snell-Bergeon, David M. Maahs, Marian Rewers, Carol Forsblom, Valma Harjutsalo, Per-Henrik Groop, John H. Fuller, Karel G. M. Moons, Trevor J. Orchard

In type 1 diabetic patients, it is important to determine absolute risk predictions in a timely manner, so that therapeutic strategies can be put into place to prevent the development of complications. In this issue, Soedamah-Muthu et al present a model they developed for predicting the major outcomes. Data were analysed from 1,973 type 1 diabetic patients followed for 7 years in the EURODIAB Prospective Complications Study. Prognostic factors of major outcomes were age, HbA1c, WHR, albumin/creatinine ratio and HDL-cholesterol. The prognostic model validated reasonably well in three different prospective US and European cohorts. After correction for systematic differences between predicted and observed risks in some cohorts, the model was able to accurately predict the patients' risk. Such a prognostic model may be helpful in clinical practice and for risk stratification in clinical trials. [Text supplied by the authors.]

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A low disposition index in adolescent offspring of mothers with gestational diabetes: a risk marker for the development of impaired glucose tolerance in youth
by Tara Holder, Cosimo Giannini, Nicola Santoro, Bridget Pierpont, Melissa Shaw, Elvira Duran, Sonia Caprio, Ram Weiss

Intra-uterine exposure to hyperglycaemia, such as occurs in of gestational diabetes (GDM), may have an adverse effect on glucose metabolism in the offspring. In this issue, Holder et al report that, in obese children and adolescents, such exposure is associated with a primary defect in beta cell function, namely a reduced oral disposition index. Compared with obese children not exposed to GDM in utero, those exposed show a failure of the beta cells to compensate adequately for increasing insulin resistance. Obese children with normal glucose tolerance exposed to GDM are at significantly increased risk for the development of impaired glucose tolerance and type 2 diabetes over a relatively short follow-up period of ~2 years. The prevalence of GDM is rising in parallel with the rise in obesity. This may indicate that a large number of children exposed to GDM are at risk for glucose tolerance deterioration, particularly if they are obese. [Text supplied by the authors.]

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Inside this issue

Reviews

Observational studies of the association between glucose-lowering medications and cardiovascular outcomes: addressing methodological limitations
Elisabetta Patorno, Amanda R. Patrick, Elizabeth M. Garry, Sebastian Schneeweiss, Victoria G. Gillet, Dorothee B. Bartels, Elvira Masso-Gonzalez, John D. Seeger

RANKL–OPG and RAGE modulation in vascular calcification and diabetes: novel targets for therapy
Agbor Ndip, Fiona L. Wilkinson, Edward B. Jude, Andrew J. M. Boulton, M. Yvonne Alexander

Meta-analyses

Prediabetes and the risk of cancer: a meta-analysis
Yi Huang, Xiaoyan Cai, Miaozhen Qiu, Peisong Chen, Hongfeng Tang, Yunzhao Hu, Yuli Huang

Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?
Zahra N. Sohani, Wei Q. Deng, Guillaume Pare, David Meyre, Hertzel C. Gerstein, Sonia S. Anan

Articles

Clinical Science and Care

Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness
Kim M. Huffman, Timothy R. Koves, Monica J. Hubal, Hiba Abouassi, Nina Beri, Lori A. Bateman, Robert D. Stevens, Olga R. Ilkayeva, Eric P. Hoffman, Deborah M. Muoio, William E. Kraus

Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
Michael C. d’Emden, Alicia J. Jenkins, Liping Li, Diana Zannino, Kristy P. Mann, James D. Best, Bronwyn G. A. Stuckey, Kris Park, Juha Saltevo, Anthony C. Keech, on behalf of the FIELD Study Investigators

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Epidemiology

Predicting major outcomes in type 1 diabetes: a model development and validation study
Sabita S. Soedamah-Muthu & Yvonne Vergouwe & Tina Costacou & Rachel G. Miller & Janice Zgibor & Nish Chaturvedi & Janet K. Snell-Bergeon & David M. Maahs & Marian Rewers & Carol Forsblom & Valma Harjutsalo & Per-Henrik Groop & John H. Fuller & Karel G. M. Moons & Trevor J. Orchard

Higher dietary salt intake is associated with microalbuminuria, but not with retinopathy in individuals with type 1 diabetes: the EURODIAB Prospective Complications Study
Lian Engelen & Sabita S. Soedamah-Muthu & Johanna M. Geleijnse & Monika Toeller & Nish Chaturvedi & John H. Fuller & Casper G. Schalkwijk & Coen D. A. Stehouwer

Development of a prediction model for fatal and non-fatal coronary heart disease and cardiovascular disease in patients with newly diagnosed type 2 diabetes mellitus: The Basque Country Prospective Complications and Mortality Study risk engine (BASCORE)
José A. Piniés & Fernando González-Carril & José M. Arteagoitia & Itziar Irigoien & Jone M. Altzibar & José L. Rodriguez-Murua & Larraitz Echevarriarteun & the Sentinel Practice Network of the Basque Country

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Genetics

Variants associated with type 2 diabetes identified by the transethnic meta-analysis study: assessment in American Indians and evidence for a new signal in LPP
Short Communication
Anup K. Nair & Yunhua Li Muller & Nellie A. McLean & Maryam Abdussamad & Paolo Piaggi & Sayuko Kobes & E. Jennifer Weil & Jeffrey M. Curtis & Robert G. Nelson & William C. Knowler & Robert L. Hanson & Leslie J. Baier

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Islet Studies

Non-neural tyrosine hydroxylase, via modulation of endocrine pancreatic precursors, is required for normal development of beta cells in the mouse pancreas
Patricia Vázquez, Ana M. Robles, Flora de Pablo, Catalina Hernández-Sánchez

von Hippel–Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation
Andrea Soggia & Cyrille Ramond & Haruhiko Akiyama & Raphaël Scharfmann & Bertrand Duvillie

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Immunology and Transplantation

In patients with type 1 diabetes simultaneous pancreas and kidney transplantation preserves long-term kidney graft ultrastructure and function better than transplantation of kidney alone
Jørn P. Lindahl & Finn P. Reinholt & Ivar A. Eide & Anders Hartmann & Karsten Midtvedt & Hallvard Holdaas & Linda T. Dorg & Trine M. Reine & Svein O. Kolset & Rune Horneland & Ole Øyen & Knut Brabrand & Trond Jenssen

A CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice
Gisela M. Vaitaitis & Michael H. Olmstead & Dan M. Waid & Jessica R. Carter & David H. Wagner Jr.

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Metabolism

Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis
Maria Keller & Susan Kralisch & Kerstin Rohde & Dorit Schleinitz & Arne Dietrich & Michael R. Schön & Daniel Gärtner & Tobias Lohmann & Miriam Dreßler & Anke Tönjes & Michael Stumvoll & Peter Kovacs & Mathias Fasshauer & Matthias Blüher & Yvonne Böttcher

Downregulation of the acetyl-CoA metabolic network in adipose tissue of obese diabetic individuals and recovery after weight loss
Harish Dharuri & Peter A. C. ’ tHoen & Jan B. van Klinken & Peter Henneman & Jeroen F. J. Laros & Mirjam A. Lips & Fatiha el Bouazzaoui & Gert-Jan B. van Ommen & Ignace Janssen & Bert van Ramshorst & Bert A. van Wagensveld & Hanno Pijl & Ko Willems van Dijk & Vanessa van Harmelen

Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice
Hongfeng Jiang, Marit Westerterp, Chunjiong Wang, Yi Zhu, Ding Ai

The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet
Joaquín Pérez-Schindler & Kristoffer Svensson & Elyzabeth Vargas-Fernández & Gesa Santos & Walter Wahli & Christoph Handschin

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Pathophysiology and Complications

A low disposition index in adolescent offspring of mothers with gestational diabetes: a risk marker for the development of impaired glucose tolerance in youth
Tara Holder & Cosimo Giannini & Nicola Santoro & Bridget Pierpont & Melissa Shaw & Elvira Duran & Sonia Caprio & Ram Weiss

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Research Letter

Neurogenin 3 is important but not essential for pancreatic islet development in humans
Oscar Rubio-Cabezas & Ethel Codner & Sarah E. Flanagan & José L. Gómez & Sian Ellard & Andrew T. Hattersley

Letters

Timing and intensity of exercise for glucose control
Elsamma Chacko

Timing and intensity of exercise for glucose control. Reply to Chacko E. [letter]
Frank W. Booth, John P. Thyfault

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Erratum

Erratum to: Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways
Ki-Suk Kim, Josephine M. Egan, Hyeung-Jin Jang

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