About us

For Authors

For Reviewers

Cover gallery

For Copy-editors

Happy 50th Anniversary to Diabetologia!


August 2015 cover

To celebrate our golden anniversary, we commissioned a group of innovative and provocative commentaries looking 50 years into the future. When we invited writers to contribute we encouraged them to hypothesise and conceptualise, challenging them to embrace ‘blue sky, left field, out of the box thinking’! The articles were then peer reviewed and are now part of this special edition.

Download the high resolution cover image

Click here to view this month's contents


50 Years Forward

Bo Ahrén Frank Booth Philippe Halban Alison Iroz
Creative use of novel glucose-lowering drugs for type 2 diabetes: where will we head in the next 50 years? Bo Ahrén The erosion of physical activity in Western societies: an economic death march Frank Booth and John Hawley 50 years forward: beta cells Philippe Halban Hepatokines: unlocking the multi-organ network in metabolic diseases Alison Iroz, Jean-Pierre Couty and Catherine Postic
Steven Kahn Mark McCarthy Juris Meier Michael Roden
Medications for type 2 diabetes: how will we be treating patients in 50 years? Steven E. Kahn and John B. Buse Genomic medicine at the heart of diabetes management Mark I. McCarthy Incretin-based therapies: where will we be 50 years from now? Juris J. Meier, Michael A. Nauck Future of muscle research in diabetes: a look into the crystal ball Michael Roden
Nicholas D F Russell Casper Schalkwijk Patrick Schrauwen Frans Schuit
50 years forward: mechanisms of hyperglycaemia-driven diabetic complications Nicholas D. F. Russell, Mark E. Cooper Vascular AGE-ing by methylglyoxal: the past, the present and the future Casper G. Schalkwijk The future of brown adipose tissues in the treatment of type 2 diabetes Patrick Schrauwen, Wouter D. van Marken Lichtenbelt, Bruce M. Spiegelman Comparative genomics: beyond the horizon of the next research grant Frans Schuit

In the News

New NICE thresholds for diabetes in pregnancy could miss up to 4,000 women per year in UK at risk of complications

Download this new research by Dr Claire Meek from the University of Cambridge and Cambridge University Hospitals Foundation Trust and colleagues.
For further information contact Dr Meek (clm70@cam.ac.uk).


(posted online 22.01h BST Thursday 11th June 2015)


Up front

Juleen Zierath

Competition for publication in Diabetologia is greater than ever, and less than 20% of papers are accepted. Of all the high-quality papers that appear in this month's issue I want to share with you five articles that I find to be of particular interest. These will be featured 'up front' in the print issue and here on our website. Juleen R. Zierath, Editor


Sick of sitting
by James A. Levine

Few of our grandparents either worked or engaged in leisure whilst sitting down. But at present, work, leisure and transportation commonly occur seated. For the last 200 years, sitting all day has been systematically enforced as a tool of economic development and financial prosperity. Movement was wrongly perceived as wasting time. In his review in this issue, James Levine reasons that we must get up. Neurologically and physiologically, people are not designed to sit a lot. Data from many scientific disciplines, gathered in millions of people across many nations, demonstrate that excess sitting is harmful. The proven health consequences of sedentariness are dire; more than 30 chronic diseases and conditions are associated with excess sitting and, sadly, people who sit too much die too soon. [Text supplied by the authors.]

Download a pdf

****************************

Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial
by The Look AHEAD Research Group

Both genetic and environmental factors collectively contribute to cardiovascular disease (CVD). In this issue, the Look AHEAD Research Group reports that a genetic risk score (GRS), encompassing the most comprehensive list of CVD loci to date, significantly predicted cardiovascular morbidity and mortality over a median follow-up of 9.6 years among overweight or obese individuals with type 2 diabetes. The highest GRS quartile experienced a 51% greater incidence of CVD compared with the lowest GRS quartile. Intensive lifestyle intervention, which focused on weight loss goals achieved through energy restriction and physical activity and resulted in significant reductions in weight and HbA1c through 9.6 years, did not mitigate this association. These findings build upon prior research by providing evidence of a prospective association of the most comprehensive GRS to date with incident cardiovascular morbidity and mortality among overweight or obese individuals with type 2 diabetes. There appears to be a need for alternative treatments to mitigate this risk. [Text supplied by the authors.]

Download a pdf

****************************

The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice
by Jason M. Spaeth, Chad S. Hunter, Lauren Bonatakis, Min Guo, Catherine A. French, Ian Slack, Manami Hara, Simon E. Fisher, Jorge Ferrer, Edward E. Morrisey, Ben Z. Stanger, Roland Stein

Jason M. Spaeth, Chad S. Hunter, Lauren Bonatakis, Min Guo, Catherine A. French, Ian Slack, Manami Hara, Simon E. Fisher, Jorge Ferrer, Edward E. Morrisey, Ben Z. Stanger, Roland Stein Factors that impact islet alpha cell development and function have become a primary interest to islet biologists, as dysregulated glucagon secretion contributes to diabetic pathophysiology. In this issue, Spaeth et al report that the forkhead box (FOX)P1, FOXP2 and FOXP4 transcriptional regulators are critical for normal alpha cell proliferation and function. Using genetically engineered mouse models, the authors demonstrated that removal of FOXP1, FOXP2 and FOXP4 from developing endocrine cells reduced postnatal alpha cell mass by nearly 85%, whereas beta cell levels and function were unaffected. Triple-compound Foxp1/2/4 conditional knockout (cKO) mutant mice were hypoglycaemic and hypoglucagonaemic, and this is likely to be the result of a reduced alpha cell mass and impaired glucagon secretion from the remaining alpha cells. These findings provide insight into the important fundamental mechanisms involved in islet alpha cell regulation and suggest potential effectors of alpha cell dysfunction in diabetes. [Text supplied by the authors.]

Download a pdf

****************************

Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery
by Jakob S. Hansen, Xinjie Zhao, Martin Irmler, Xinyu Liu, Miriam Hoene, Mika Scheler, Yanjie Li, Johannes Beckers, Martin Hrab? de Angelis, Hans-Ulrich Häring, Bente K. Pedersen, Rainer Lehmann, Guowang Xu, Peter Plomgaard, Cora Weigert

The ability of physical activity to prevent and treat type 2 diabetes is widely accepted. However, the impact of the disease on the regulation of fuel supply and oxidation and gene expression during exercise is less clear. In this issue, Hansen et al report that the beneficial effects of one 60 min bout of exercise at 50% of maximal oxygen consumption (VO2max) on glucose and fatty acid metabolism are not diminished in type 2 diabetic patients compared with controls with normal glucose tolerance. Specific metabolic and transcriptional adaptations in diabetic skeletal muscle after exercise indicate that the response by regulators of glucose and amino acid metabolism is even more pronounced in type 2 diabetic patients. These data suggest that diabetic patients can receive great benefits from moderately intense exercise and suggest mechanisms that can potentially be targeted to ameliorate the dysregulated glucose and amino acid metabolism in type 2 diabetes. [Text supplied by the authors.]

Download a pdf

****************************

Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes
by Francoise Koumanov, Vinit J. Pereira, Judith D. Richardson, Samantha L. Sargent, Daniel J. Fazakerley, Geoffrey D. Holman

Members of the Rab family of G-proteins are thought to provide bridges between known early insulin signalling steps and membrane vesicle traffic. However, the identities of the key Rab proteins, the extent to which they are activated by insulin, and the mechanisms of linkage to GLUT4 vesicle exocytosis are currently largely unknown. In this issue, Koumanov et al present the results of a study in which they used a novel combination of photolabelling and proteomics to identify Rab3 as a key intermediate linking insulin action with the fusion of GLUT4 vesicles with the plasma membrane. Rab3 function is shown to be closely tied to an insulin-controlled complex with its negative effector protein Noc2 at the plasma membrane. These findings have parallels with the mechanism by which insulin-containing vesicles are released from pancreatic beta cells and suggest that common therapeutic drug targets could be identified, allowing concurrent stimulation of pancreatic insulin release and peripheral glucose uptake and metabolism. [Text supplied by the authors.]

Download a pdf

Back to top

Inside this issue

Editorial

Diabetologia at 50: celebrating half a century of progress in diabetes research and care
Juleen R. Zierath

Commentaries

50 years forward: beta cells
Philippe A. Halban

Future of muscle research in diabetes: a look into the crystal ball
Michael Roden

Hepatokines: unlocking the multi-organ network in metabolic diseases
Alison Iroz, Jean-Pierre Couty, Catherine Postic

The future of brown adipose tissues in the treatment of type 2 diabetes
Patrick Schrauwen, Wouter D. van Marken Lichtenbelt, Bruce M. Spiegelman

50 years forward: mechanisms of hyperglycaemia-driven diabetic complications
Nicholas D. F. Russell, Mark E. Cooper

Vascular AGE-ing by methylglyoxal: the past, the present and the future
Casper G. Schalkwijk

Comparative genomics: beyond the horizon of the next research grant
Frans Schuit

Genomic medicine at the heart of diabetes management
Mark I. McCarthy

The erosion of physical activity in Western societies: an economic death march
Frank W. Booth, John A. Hawley

Medications for type 2 diabetes: how will we be treating patients in 50 years?
Steven E. Kahn, John B. Buse

Creative use of novel glucose-lowering drugs for type 2 diabetes: where will we head in the next 50 years?
Bo Ahrén

Incretin-based therapies: where will we be 50 years from now?
Juris J. Meier, Michael A. Nauck

Review

Sick of sitting
James A. Levine

Articles

Clinical Science and Care

GIP increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: a randomised trial
Özlem Gögebakan, Martin A. Osterhoff, Rita Schüler, Olga Pivovarova, Michael Kruse, Anne-Cathrin Seltmann, Alexander S. Mosig, Natalia Rudovich, Michael Nauck, Andreas F. H. Pfeiffer

Effects of exogenous glucagon-like peptide-1 on blood pressure, heart rate, gastric emptying, mesenteric blood flow and glycaemic responses to oral glucose in older individuals with normal glucose tolerance or type 2 diabetes
Laurence G. Trahair, Michael Horowitz, Julie E. Stevens, Christine Feinle-Bisset, Scott Standfield, Diana Piscitelli, Christopher K. Rayner, Adam M. Deane, Karen L. Jones

Back to top of this issue list

Epidemiology

All-cause mortality in a nationwide cohort of childhood-onset diabetes in Norway 1973–2013
Vibeke Gagnum, Lars C. Stene, Leiv Sandvik, Morten W. Fagerland, Pål R. Njølstad, Geir Joner, Torild Skrivarhaug

OGTT and random plasma glucose in the prediction of type 1 diabetes and time to diagnosis
Olli Helminen, Susanna Aspholm, Tytti Pokka, Jorma Ilonen, Olli Simell, Riitta Veijola, Mikael Knip

Inverse association between fasting plasma glucose and risk of ventricular arrhythmias
Francesco Zaccardi, David R. Webb, Sudhir Kurl, Kamlesh Khunti, Melanie J. Davies, Jari A. Laukkanen

Back to top of this issue list

Genetics

Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial
The Look AHEAD Research Group

Back to top of this issue list

Islet Studies

Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas)
Rodolfo Guardado Mendoza, Carla Perego, Giovanna Finzi, Stefano La Rosa, Carlo Capella, Lilia M. Jimenez-Ceja, Licio A. Velloso, Mario J. A. Saad, Fausto Sessa, Federico Bertuzzi, Stefania Moretti, Edward J. Dick Jr., Alberto M. Davalli, Franco Folli

Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice
Anna Motterle, Sonia Gattesco, Dorothée Caille, Paolo Meda, Romano Regazzi

The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice
Jason M. Spaeth, Chad S. Hunter, Lauren Bonatakis, Min Guo, Catherine A. French, Ian Slack, Manami Hara, Simon E. Fisher, Jorge Ferrer, Edward E. Morrisey, Ben Z. Stanger, Roland Stein

Back to top of this issue list

Metabolism

Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery
Jakob S. Hansen, Xinjie Zhao, Martin Irmler, Xinyu Liu, Miriam Hoene, Mika Scheler, Yanjie Li, Johannes Beckers, Martin Hrabe de Angelis, Hans-Ulrich Häring, Bente K. Pedersen, Rainer Lehmann, Guowang Xu, Peter Plomgaard, Cora Weigert

A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control
Noha A. Yousri, Dennis O. Mook-Kanamori, Mohammed M. El-Din Selim, Ahmed H. Takiddin, Hala Al-Homsi, Khoulood A. S. Al-Mahmoud, Edward D. Karoly, Jan Krumsiek, Kieu Thinh Do, Ulrich Neumaier, Marjonneke J. Mook-Kanamori, Jillian Rowe, Omar M. Chidiac, Cindy McKeon, Wadha A. Al Muftah, Sara Abdul Kader, Gabi Kastenmüller, Karsten Suhre

Oncostatin M is a potential agent for the treatment of obesity and related metabolic disorders: a study in mice
Tadasuke Komori, Minoru Tanaka, Hiroto Furuta, Takashi Akamizu, Atsushi Miyajima, Yoshihiro Morikawa

Insulin regulates Rab3–Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes
Francoise Koumanov, Vinit J. Pereira, Judith D. Richardson, Samantha L. Sargent, Daniel J. Fazakerley, Geoffrey D. Holman

Intestinal mTOR regulates GLP-1 production in mouse L cells
Geyang Xu, Ziru Li, Li Ding, Hong Tang, Song Guo, Hongbin Liang, Huadong Wang, Weizhen Zhang

Back to top of this issue list

Pathophysiology and Complications

Infrared thermographic assessment of changes in skin temperature during hypoglycaemia in patients with type 1 diabetes
Anne-Sophie Sejling, Kai H. W. Lange, Christian S. Frandsen, Sarah S. Diemar, Lise Tarnow, Jens Faber, Jens J. Holst, Bolette Hartmann, Linda Hilsted, Troels W. Kjaer, Claus B. Juhl, Birger Thorsteinsson, Ulrik Pedersen-Bjergaard

Insulin-induced changes in skeletal muscle microvascular perfusion are dependent upon perivascular adipose tissue in women
Rick I. Meijer, Erik H. Serné, H. Ibrahim Korkmaz, Donald L. van der Peet, Michiel P. de Boer, Hans W. M. Niessen, Victor W. M. van Hinsbergh, John S. Yudkin, Yvo M. Smulders, Etto C. Eringa

Impact of high dose n-3 polyunsaturated fatty acid treatment on measures of microvascular function and vibration perception in non-alcoholic fatty liver disease: results from the randomised WELCOME trial
Keith G. McCormick, Eleonora Scorletti, Lokpal Bhatia, Philip C. Calder, Michael J. Griffin, Geraldine F. Clough, Christopher D. Byrne

Diabetes with poor glycaemic control does not promote atherosclerosis in genetically modified hypercholesterolaemic minipigs
Rozh H. Al-Mashhadi, Martin M. Bjørklund, Martin B. Mortensen, Christina Christoffersen, Torben Larsen, Erling Falk, Jacob F. Bentzon

Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway
Chi Zhang, Zhifeng Huang, Junlian Gu, Xiaoqing Yan, Xuemian Lu, Shanshan Zhou, Shudong Wang, Minglong Shao, Fangfang Zhang, Peng Cheng, Wenke Feng, Yi Tan, Xiaokun Li

Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice
Dong Zheng, Jian Ma, Yong Yu, Minghui Li, Rui Ni, Grace Wang, Ruizhen Chen, Jianmin Li, Guo-Chang Fan, James C. Lacefield, Tianqing Peng

Back to top of this issue list

Letters

Analysis of peri-islet CD45-positive leucocytic infiltrates in long-standing type 1 diabetic patients: additional data regarding cause of death
Shiva Reddy, Nina Zeng, Hussam Al-Diery, Doran Jung, Clifton Yeu, Maximilian O. Joret, Mervyn J. Merrilees, Fiona Wu

Variable effects of statins on glucose homeostasis parameters and their diabetogenic role
Michael S. Kostapanos, Aris P. Agouridis, Moses S. Elisaf

Variable effects of statins on glucose homeostasis parameters and their diabetogenic role. Reply to Kostapanos MS, Agouridis AP and Elisaf MS [letter]
Henna Cederberg, Markku Laakso

Back to top