About us

For Authors

For Reviewers

Cover gallery

For Copy-editors

Welcome to Diabetologia

Diabetologia publishes original clinical and experimental research within the field of diabetes. We are interested in papers that convey new information or insight into any aspect of the condition, ranging from basic science to clinical applications. These are judged in terms of their scientific quality, novelty, relevance and interest to our broadly based readership.

In Memoriam

Professor Michaela Diamant, 1962–2014

Michaela Diamant

We are saddened by the untimely death of Professor Michaela Diamant who served as an Associate Editor for Diabetologia from 2005 to 2009 and as an Editorial Board member in 2010 and 2011. She also served the EASD with distinction, with involvement in the programme and abstract review committees, and the organising committee for the EASD meeting in Amsterdam in 2007.
Read her obituary by Robert J Heine, Hannele Yki-Järvinen, Steven E. Kahn and Daniel H. van Raalte


In the News

Sweden has 2–3 times as many adolescents and young adults with type 1 diabetes as previously thought

Download this new research by Dr Araz Rawshani from Swedish National Diabetes Register, Gothenburg, Sweden, and colleagues.
For further information contact Dr Rawshani (araz.rawshani@gu.se).


(posted online 23.01 h BST Sunday 6 April 2014)


Current issue: May 2014

May 2014 cover

Click here to view this month's contents

The cover picture shows a heat map of differentially expressed genes in the liver following the administration of ezetimibe; upregulated genes are shown in yellow and downregulated genes in blue. This heat map sheds light on previously unrecognised actions of this cholesterol absorption inhibitor. In the present issue of Diabetologia Takeshita et al present the results of a randomised controlled trial in patients with non-alcoholic fatty liver disease, in which ezetimibe improved hepatic fibrosis, but also increased levels of hepatic long-chain fatty acids and HbA1c.

Cover credit: Yumie Takeshita, Toshinari Takamura and Masao Honda, Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Sciences, Ishikawa, Japan

Download the high resolution cover image

Up front

Juleen Zierath

Competition for publication in Diabetologia is greater than ever, and less than 20% of papers are accepted. Of all the high-quality papers that appear in this month's issue I want to share with you five articles that I find to be of particular interest. These will be featured 'up front' in the print issue and here on our website. Juleen R. Zierath, Editor


Self-monitoring of blood glucose: a promise still unfulfilled?
by Simon R. Heller

Although self-monitoring of blood glucose (SMBG) has become an indispensible part of self-management for individuals treated with insulin, the evidence that it improves blood glucose control or even reduces hypoglycaemia is surprisingly scanty. In this issue, Simon Heller has provided a commentary regarding SMBG in type 2 diabetes to accompany a paper by Nauck et al. Repeated trials have generally reported minimal or no improvement in HbA1c or hypoglycaemia. Other research has reported worse psychological outcomes, with increased anxiety and depression. Some authorities have used these results as a reason to prevent or limit the use of testing, particularly in type 2 diabetes. The evidence suggests that those who derive no benefit might be encouraged to stop testing, with blood glucose control monitored in other ways. However, many patients still find it an indispensable part of their management. Professional carers should develop an individual approach to monitoring, encouraging those who find monitoring valuable, but stopping it in those whose blood glucose control does not improve or those who experience deteriorating psychological outcomes. [Text supplied by the authors.]

Download a pdf

****************************

Nuclear receptors and metabolism: from feast to famine
by Suk-Hyun Hong, Maryam Ahmadian, Ruth T. Yu, Annette R. Atkins, Michael Downes, Ronald M. Evans

Since the initial discovery of nuclear hormone receptors (NHRs) and the identification of the lipophilic hormones that function as their ligands, their control of whole body physiology has been a principal focus of study. In this issue, Hong et al review the critical role of NHRs in coordinating multiple metabolic organs to preserve whole body metabolic homeostasis during the daily cycles of feast and famine. To achieve this remarkable metabolic balancing act, NHRs sense nutrient levels and regulate a plethora of genetic switches and metabolic pathways to either store excess nutrients or mobilise stored nutrients to generate the primary energy currency of cells, ATP, in addition to other biomolecules. This review highlights new discoveries in NHR-mediated pathways in both the fed and fasted state, as well as their role in driving circadian rhythmicity and, thereby, metabolic homeostasis. [Text supplied by the authors.]

Download a pdf

****************************

Dietary dairy product intake and incident type 2 diabetes: a prospective study using dietary data from a 7-day food diary
by Laura M. O'Connor, Marleen A. H. Lentjes, Robert N. Luben, Kay-Tee Khaw, Nicholas J. Wareham, Nita G. Forouhi

Evidence is emerging that overall dairy product consumption may be related to a lower risk of developing type 2 diabetes, but there is insufficient information on specific types of dairy products in relation to diabetes risk. In this issue, O'Connor et al report that higher consumption of low-fat fermented dairy products is associated with a lower risk of new-onset diabetes over 11 years, compared with non-consumption. The low-fat fermented dairy products consumed largely (87%) consisted of yoghurt but also included unripened cheese, such as fromage frais and low-fat cottage cheese, in a middle-aged population in the UK. No other dairy intake (total dairy, high-fat or low-fat total dairy, milk or cheese) was associated with type 2 diabetes. These findings suggest that specific types of dairy product may help prevent diabetes. They also highlight the importance of considering food group subtypes, rather than overall food-group categories, when examining the role of diet in the prevention of chronic diseases. [Text supplied by the authors.]

Download a pdf

****************************

Sex differences in the risk of stroke and HbA1c among diabetic patients
by Wenhui Zhao, Peter T. Katzmarzyk, Ronald Horswell, Yujie Wang, Jolene Johnson, Gang Hu

Type 2 diabetes is an independent risk factor for stroke, but how much its effect varies by sex is uncertain. Because randomised clinical trials and meta-analyses have failed to show a benefit of intensive glucose control on rates of stroke, more observational data are needed to assess whether there is a sex-specific association between HbA1c and the risk of stroke among diabetic patients. In this issue, Zhao et al report that, among individuals with type 2 diabetes, high HbA1c levels are associated with an increased risk of stroke among women but not among men. This graded positive association was more significant in women 55 years than in younger women. It would be important to take this into consideration when planning a strategy to prevent cardiovascular disease, especially for women with type 2 diabetes. [Text supplied by the authors.]

Download a pdf

****************************

Mortality after cancer among patients with diabetes mellitus: effect of diabetes duration and treatment
by Kristina Ranc, Marit E. Jørgensen, Søren Friis, Bendix Carstensen

Although the evidence on the relationship between diabetes and cancer continues to grow, few studies have addressed associations between different types of glucose-lowering therapies and survival after cancer diagnosis, and how these associations vary with duration of diabetes and by time since diagnosis of cancer. In this issue, Ranc et al report the results of a register-based study, which suggest that the mortality of cancer patients with pre-existing diabetes is substantially higher than that of non-diabetic patients, for all cancer overall as well as for most individual cancer sites. The highest mortality rate ratio was observed among insulin-treated patients, suggesting that cancer patients who receive more intensive diabetes treatment have a larger degree of comorbidity at the time of cancer diagnosis and, hence, poorer survival. These findings call for improved monitoring and optimised diabetes treatment of cancer patients with diabetes-a therapeutic challenge requiring close collaboration between oncologists and endocrinologists. [Text supplied by the authors.]

Download a pdf

Back to top
******************************************************

Inside this issue

Commentaries

Self-monitoring of blood glucose: a promise still unfulfilled?
Simon R. Heller

Ezetimibe in the balance: can cholesterol-lowering drugs alone be an effective therapy for NAFLD?
Giovanni Musso

Inside the pancreas: progress and challenges of human beta cell mass quantification
Markus Tiedge

Review

Nuclear receptors and metabolism: from feast to famine
Suk-Hyun Hong, Maryam Ahmadian, Ruth T. Yu, Annette R. Atkins, Michael Downes, Ronald M. Evans

Articles

Clinical Science and Care

A randomised, controlled trial of self-monitoring of blood glucose in patients with type 2 diabetes receiving conventional insulin treatment
Michael A. Nauck, Burkhard Haastert, Christoph Trautner, Ulrich A. Müller, Matthias A. Nauck, Lutz Heinemann

The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial
Yumie Takeshita, Toshinari Takamura, Masao Honda, Yuki Kita, Yoh Zen, Ken-ichiro Kato, Hirofumi Misu, Tsuguhito Ota, Mikiko Nakamura, Kazutoshi Yamada, Hajime Sunagozaka, Kuniaki Arai, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko

Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes
David Polidori, Andrea Mari, Ele Ferrannini

Back to top of this issue list

Epidemiology

Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression
Jennifer Raab, Eleni Z. Giannopoulou, Simone Schneider, Katharina Warncke, Miriam Krasmann, Christiane Winkler, Anette-Gabriele Ziegler

Dietary dairy product intake and incident type 2 diabetes: a prospective study using dietary data from a 7-day food diary
Laura M. O’Connor, Marleen A. H. Lentjes, Robert N. Luben, Kay-Tee Khaw, Nicholas J. Wareham, Nita G. Forouhi

Sex differences in the risk of stroke and HbA1c among diabetic patients
Wenhui Zhao, Peter T. Katzmarzyk, Ronald Horswell, Yujie Wang, Jolene Johnson, Gang Hu

Mortality after cancer among patients with diabetes mellitus: effect of diabetes duration and treatment
Kristina Ranc, Marit E. Jørgensen, Søren Friis, Bendix Carstensen

Circulating natriuretic peptide concentrations reflect changes in insulin sensitivity over time in the Diabetes Prevention Program
Short Communication
Geoffrey A. Walford, Yong Ma, Costas A. Christophi, Ronald B. Goldberg, Petr Jarolim, Edward Horton, Kieren J. Mather, Elizabeth Barrett-Connor, Jaclyn Davis, Jose C. Florez, Thomas J. Wang

Validation of metabolic syndrome score by confirmatory factor analysis in children and adults and prediction of cardiometabolic outcomes in adults
Anna Viitasalo, Timo A. Lakka, David E. Laaksonen, Kai Savonen, Hanna-Maaria Lakka, Maija Hassinen, Pirjo Komulainen, Tuomo Tompuri, Sudhir Kurl, Jari A. Laukkanen, Rainer Rauramaa

Back to top of this issue list

Islet Studies

Non-invasive quantification of the beta cell mass by SPECT with 111In-labelled exendin
Maarten Brom, Wietske Woliner-van der Weg, Lieke Joosten, Cathelijne Frielink, Thomas Bouckenooghe, Paul Rijken, Karolina Andralojc, Burkhard J. Göke, Marion de Jong, Decio L. Eizirik, Martin Béhé, Tony Lahoutte, Wim J. G. Oyen, Cees J. Tack, Marcel Janssen, Otto C. Boerman, Martin Gotthardt

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass
Latif Rachdi, Dulanjalee Kariyawasam, Fanny Guez, Virginie Aïello, Maria L. Arbonés, Nathalie Janel, Jean-Maurice Delabar, Michel Polak, Raphaël Scharfmann

In vivo activation of the PI3K–Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes
Elina Hakonen, Jarkko Ustinov, Décio L. Eizirik, Hannu Sariola, Päivi J. Miettinen, Timo Otonkoski

Back to top of this issue list

Immunology and Transplantation

Pharmacological application of carbon monoxide ameliorates islet-directed autoimmunity in mice via anti-inflammatory and anti-apoptotic effects
Ivana Nikolic, Tamara Saksida, Katia Mangano, Milica Vujicic, Ivana Stojanovic, Ferdinando Nicoletti, Stanislava Stosic-Grujicic

Pancreatic duct cells as a source of VEGF in mice
Xiangwei Xiao, Krishna Prasadan, Ping Guo, Yousef El-Gohary, Shane Fischbach, John Wiersch, Iljana Gaffar, Chiyo Shiota, George K. Gittes

Back to top of this issue list

Metabolism

The effect of a single 2 h bout of aerobic exercise on ectopic lipids in skeletal muscle, liver and the myocardium
Short Communication
Julie Bucher, Marion Krüsi, Thomas Zueger, Michael Ith, Christoph Stettler, Peter Diem, Chris Boesch, Roland Kreis, Emanuel Christ

A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance
Jonas M. Kristensen, Vibe Skov, Stine J. Petersson, Niels Ørtenblad, Jørgen. F. P. Wojtaszewski, Henning Beck-Nielsen, Kurt Højlund

Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing
Sally Yu Shi, Cynthia T. Luk, Jara J. Brunt, Tharini Sivasubramaniyam, Shun-Yan Lu, Stephanie A. Schroer, Minna Woo

Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice
Liping Qiao, Hyung sun Yoo, Chris Bosco, Bonggi Lee, Gen-Sheng Feng, Jerome Schaack, Nai-Wen Chi, Jianhua Shao

Back to top of this issue list

Pathophysiology and Complications

miR-195 regulates SIRT1-mediated changes in diabetic retinopathy
Rokhsana Mortuza, Biao Feng, Subrata Chakrabarti

TIAM1–RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy
Renu A. Kowluru, Anjaneyulu Kowluru, Rajakrishnan Veluthakal, Ghulam Mohammad, Ismail Syed, Julia M. Santos, Manish Mishra

Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells
Dorothea I. Siegel-Axel, Susanne Ullrich, Norbert Stefan, Kilian Rittig, Felicia Gerst, Christian Klingler, Ulrike Schmidt, Birgit Schreiner, Elko Randrianarisoa, Hans-Eberhard Schaller, Ulrich A. Stock, Cora Weigert, Alfred Königsrainer, Hans-Ulrich Häring

Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses
Dmitry Namgaladze, Sebastian Lips, Thomas J. Leiker, Robert C. Murphy, Kim Ekroos, Nerea Ferreiros, Gerd Geisslinger, Bernhard Brüne

Back to top of this issue list

Research Letter

Striatal dopamine receptor binding in morbidly obese women before and after gastric bypass surgery and its relationship with insulin sensitivity
Barbara A. de Weijer, Elsmarieke van de Giessen, Ignace Janssen, Frits J. Berends, Arnold van de Laar, Mariette T. Ackermans, Eric Fliers, Susanne E. la Fleur, Jan Booij, Mireille J. Serlie

Back to top

Letters

Matrix metalloproteinase-10 and microvascular complications of type 1 diabetes: might vitamin D status be relevant?
Barbara J. Boucher

Should women with diabetic nephropathy considering pregnancy continue ACE inhibitor or angiotensin II receptor blocker therapy until pregnancy is confirmed?
Gareth Lewis, Alexander P. Maxwell

Should women with diabetic nephropathy considering pregnancy continue ACE inhibitor or angiotensin II receptor blocker therapy until pregnancy is confirmed? Reply to Lewis G and Maxwell AP [letter]
Peter W. G. Tennant, Svetlana V. Glinianaia, Rudy W. Bilous, Judith Rankin, Ruth Bell

Back to top

Erratum

Erratum to: Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model
Authors Danielle J. Borg, Marc Weigelt, Carmen Wilhelm, Michael Gerlach, Marc Bickle, Stephan Speier, Ezio Bonifacio, Angela Hommel

Back to top