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Welcome to Diabetologia

Diabetologia publishes original clinical and experimental research within the field of diabetes. We are interested in papers that convey new information or insight into any aspect of the condition, ranging from basic science to clinical applications. These are judged in terms of their scientific quality, novelty, relevance and interest to our broadly based readership.

Statement of Principle

Joint Statement of Principle from the EASD, ADA, AACE and TES (November 2014)

In the News

Serious life events in childhood can triple risk of developing type 1 diabetes

Download this new research by Maria Nygren in collaboration with Professor Johnny Ludvigsson and Dr Anneli Frostell and other colleagues, all from Linköping University, Sweden.
For further information contact Ms Nygren (maria.nygren@liu.se), Professor Ludvigsson (johnny.ludvigsson@liu.se) or Dr Frostell (anneli.frostell@liu.se).


(posted online 22.01h GMT Thursday 9th April 2015)

Study finds each hour spent watching TV daily increases the risk of developing diabetes by 3.4%

Download this new research by Drs Bonny Rockette-Wagner (lead author) and Andrea Kriska (senior author) from the University of Pittsburgh, PA, USA, and colleagues.
For further information contact Allison Hydzik in the University of Pittsburgh Media Office (hydzikam@upmc.edu).


(posted online 22.01 h GMT Wednesday 1st April 2015)

Current issue: May 2015

May 2015 cover

Click here to view this month's contents

The cover picture shows a scanning electron micrograph of a single brown fat cell surrounded by capillaries. Under certain conditions in mice, these cells are responsible for increasing whole body energy expenditure by as much as fivefold above resting levels. With the discovery of tissue containing similar cells in humans, understanding brown fat regulation is pivotal to elucidating the dynamics of weight gain and responses to dieting and over-eating, and for the development of potential anti-obesity therapeutics. In the present issue of Diabetologia, Carey et al report that, contrary to expectations based on rodent studies, daily treatment with the drug ephedrine decreases brown fat function in healthy men.


Cover credit: PROF. S. CINTI/SCIENCE PHOTO LIBRARY

Download the high resolution cover image

Up front

Juleen Zierath

Competition for publication in Diabetologia is greater than ever, and less than 20% of papers are accepted. Of all the high-quality papers that appear in this month's issue I want to share with you five articles that I find to be of particular interest. These will be featured 'up front' in the print issue and here on our website. Juleen R. Zierath, Editor


Insulin pump risks and benefits: a clinical appraisal of pump safety standards, adverse event reporting and research needs. A Joint Statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group
by Lutz Heinemann, G. Alexander Fleming, John R. Petrie, Reinhard W. Holl, Richard M. Bergenstal, Anne L. Peters

Insulin pump therapy-continuous subcutaneous insulin infusion (CSII)-is a rapidly evolving technology that provides a flexible means of achieving glycaemic control for people with type 1 diabetes. However, users can be exposed to serious hazards if insulin delivery is interrupted or, alternatively, if excessive insulin is delivered. In this issue, the EASD and the ADA have joined forces to recommend an overhaul of the systems in place to ensure the safety of these medical devices. The report contains the following specific recommendations based on a comprehensive review of the evidence: harmonisation of international regulatory standards; greater transparency and information-sharing between agencies; more 'real-world' testing of product reliability; and an uplift in the funding available for both registry-based studies and clinical trials. Addressing these recommendations will require action from regulators, manufacturers, healthcare teams, professional associations, funding bodies-and pump users themselves. It is hoped that full adoption of the Working Group's recommendations will help maximise the benefits of CSII for people with diabetes in the coming years. [Text supplied by the authors.]

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High-energy breakfast with low-energy dinner decreases overall daily hyperglycaemia in type 2 diabetic patients: a randomised clinical trial
by Daniela Jakubowicz, Julio Wainstein, Bo Ahrén, Yosefa Bar-Dayan, Zohar Landau, Hadas R. Rabinovitz, Oren Froy

More than 382 million people worldwide are estimated to have diabetes, predominately type 2 diabetes. In these individuals, high glucose spikes after meals can be life-threatening, increasing the risk of cardiovascular complications. Therefore, mitigation of glucose excursions after meals is a major aim of type 2 diabetes treatment. In this issue, Jakubowicz et al report that a diet that contains a high-energy breakfast and more modest dinner is more effective than one that includes a high-energy dinner and reduced-energy breakfast at lowering post-meal glucose surges throughout the day. The authors suggest that such a regimen could be used as a therapeutic approach for improving glycaemic control and may potentially reduce cardiovascular complications in type 2 diabetic patients. [Text supplied by the authors.]

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Impact of cancer on adherence to glucose-lowering drug treatment in individuals with diabetes
by Marjolein M. J. Zanders, Harm R. Haak, Myrthe P. P. van Herk-Sukel, Lonneke V. van de Poll-Franse, Jeffrey A. Johnson

The majority of diabetes and cancer research has focused on the influence of glucose-lowering drugs (GLDs) on outcomes after cancer diagnosis. On the other hand, cancer might affect outcomes associated with diabetes, for example, by affecting adherence to prescribed GLDs. In this issue, Zanders and colleagues report the results of an analysis among new GLD users, which indicated that a diagnosis of cancer negatively influenced adherence to GLDs, represented by the difference in medication possession ratio (MPR) between cases and controls. The largest MPR decreases at cancer diagnosis were seen among patients with stage IV disease and gastrointestinal or pulmonary cancers. Among these patients, adherence to GLDs might be important, to prevent recurrent hyperglycaemia or diabetes complications. The authors therefore suggest that the reason for the decrease in adherence needs to be further investigated-for example, is it the patient who prioritises the fight against cancer over the effort required to maintain good metabolic control? [Text supplied by the authors.]

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Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study
by Therese Tillin, Alun D. Hughes, Qin Wang, Peter Würtz, Mika Ala-Korpela, Naveed Sattar, Nita G. Forouhi, Ian F. Godsland, Sophie V. Eastwood, Paul M. McKeigue, Nish Chaturvedi

Conventional risk factors do not fully explain the high risk of type 2 diabetes in people of South Asian descent. In this issue, Tillin et al report findings from the first longitudinal study to examine links between amino acid levels and diabetes incidence in people of both European and South Asian descent living in one geographical area. In this British population-based cohort, studied since 1988, baseline amino acid levels (particularly tyrosine and branched chain) were higher and more strongly predicted incident diabetes in the South Asians. Previous studies have provided evidence that South Asians have less lean muscle tissue, more hepatic fat and larger and more poorly functioning abdominal adipocytes than Europeans. The authors suggest that future research might focus on a functional analysis of these tissues in conjunction with biochemical studies of metabolic pathways involving amino acids, to identify novel aetiological mechanisms and potential treatment targets for diabetes in this ethnic group. [Text supplied by the authors.]

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Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort
by Henna Cederberg, Alena Stančáková, Nagendra Yaluri, Shalem Modi, Johanna Kuusisto, Markku Laakso

Statin treatment is widely used in the prevention of cardiovascular disease. Recent trials have provided evidence that statin treatment increases the risk of diabetes by about 10%, but the mechanisms explaining the diabetogenic effects of statin therapy remain largely unknown. In this issue, Cederberg et al report the results of an analysis of data on the Finnish population-based Metabolic Syndrome in Men (METSIM) cohort, comprising 8,749 non-diabetic participants who were followed up for 5.9 years. Among the 2,142 participants who were receiving statin treatment at recruitment, the risk of diabetes was increased by 46%, suggesting a higher risk of diabetes in the general population than previously reported. Additionally, statin treatment was associated with a 24% reduction in insulin sensitivity and a 12% reduction in insulin secretion. These findings suggest that the increased risk of diabetes in people on statin therapy may have been underestimated and that the diabetogenic effects of statin therapy include increased insulin resistance and decreased insulin secretion. [Text supplied by the authors.]

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Inside this issue

Commentary

Pairing-up SOX to kick-start beta cell genesis
Anne Grapin-Botton, Philip Allan Seymour, Gérard Gradwohl

Joint Statement

Insulin pump risks and benefits: a clinical appraisal of pump safety standards, adverse event reporting and research needs. A Joint Statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group
Lutz Heinemann, G. Alexander Fleming, John R. Petrie, Reinhard W. Holl, Richard M. Bergenstal, Anne L. Peters

Reviews

The clinical implications of recent studies on the structure and function of the retinal microvasculature in diabetes
Carol Yimlui Cheung, M. Kamran Ikram, Ronald Klein, Tien Yin Wong

Pathophysiology of diabetic dyslipidaemia: where are we?
Bruno Vergès

Meta-analysis

Identification of microRNA biomarkers in type 2 diabetes: a meta-analysis of controlled profiling studies
Hongmei Zhu, Siu Wai Leung

Articles

Clinical Science and Care

High-energy breakfast with low-energy dinner decreases overall daily hyperglycaemia in type 2 diabetic patients: a randomised clinical trial
Daniela Jakubowicz, Julio Wainstein, Bo Ahrén, Yosefa Bar-Dayan, Zohar Landau, Hadas R. Rabinovitz, Oren Froy

Reduction of insulinotropic properties of GLP-1 and GIP after glucocorticoid-induced insulin resistance
Marie Eriksen, David H. Jensen, Siri Tribler, Jens J. Holst, Sten Madsbad, Thure Krarup

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Epidemiology

Leisure-time physical activity and development and progression of diabetic nephropathy in type 1 diabetes: the FinnDiane Study
Johan Wadén, Heidi K. Tikkanen, Carol Forsblom, Valma Harjutsalo, Lena M. Thorn, Markku Saraheimo, Nina Tolonen, Milla Rosengård-Bärlund, Daniel Gordin, Heikki O. Tikkanen, Per-Henrik Groop, on behalf of the FinnDiane Study Group

Testing the fuel-mediated hypothesis: maternal insulin resistance and glucose mediate the association between maternal and neonatal adiposity, the Healthy Start study
Short Communication
Allison L. B. Shapiro, Sarah J. Schmiege, John T. Brinton, Deborah Glueck, Tessa L. Crume, Jacob E. Friedman, Dana Dabelea

Risk of dementia in patients hospitalised with type 1 and type 2 diabetes in England, 1998–2011: a retrospective national record linkage cohort study
Kate Smolina, Clare J. Wotton, Michael J. Goldacre

Impact of cancer on adherence to glucose-lowering drug treatment in individuals with diabetes
Marjolein M. J. Zanders, Harm R. Haak, Myrthe P. P. van Herk-Sukel, Lonneke V. van de Poll-Franse, Jeffrey A. Johnson

Serum albumin concentration and incident type 2 diabetes risk: new findings from a population-based cohort study
Setor K. Kunutsor, Hassan Khan, Jari A. Laukkanen

Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study
Therese Tillin, Alun D. Hughes, Qin Wang, Peter Würtz, Mika Ala-Korpela, Naveed Sattar, Nita G. Forouhi, Ian F. Godsland, Sophie V. Eastwood, Paul M. McKeigue, Nish Chaturvedi

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study
Jeffrey P. Krischer, Kristian F. Lynch, Desmond A. Schatz, Jorma Ilonen, Åke Lernmark, William A. Hagopian, Marian J. Rewers, Jin-Xiong She, Olli G. Simell, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Ezio Bonifacio, the TEDDY Study Group

Metabolic factors and genetic risk mediate familial type 2 diabetes risk in the Framingham Heart Study
Sridharan Raghavan, Bianca Porneala, Nicola McKeown, Caroline S. Fox, Josée Dupuis, James B. Meigs

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Genetics

Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study
Frida Renström, Robert W. Koivula, Tibor V. Varga, Göran Hallmans, Hindrik Mulder, Jose C. Florez, Frank B. Hu, Paul W. Franks

Genetic and phenotypic correlations between surrogate measures of insulin release obtained from OGTT data
Anette P. Gjesing, Rasmus Ribel-Madsen, Marie N. Harder, Hans Eiberg, Niels Grarup, Torben Jørgensen, Claus T. Ekstrøm, Oluf Pedersen, Torben Hansen

Islet Studies

SOX4 cooperates with neurogenin 3 to regulate endocrine pancreas formation in mouse models
Eric E. Xu, Nicole A. J. Krentz, Sara Tan, Sam Z. Chow, Mei Tang, Cuilan Nian, Francis C. Lynn

Analysis of peri-islet CD45-positive leucocytic infiltrates in long-standing type 1 diabetic patients
Shiva Reddy, Nina Zeng, Hussam Al-Diery, Doran Jung, Clifton Yeu, Maximilian O. Joret, Mervyn J. Merrilees, Fiona Wu

In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats
Jiaxi Chen, Shuyuan Chen, Pintong Huang, Xing-Li Meng, Sandra Clayton, Jin-Song Shen, Paul A. Grayburn

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Metabolism

Chronic ephedrine administration decreases brown adipose tissue activity in a randomised controlled human trial: implications for obesity
Andrew L. Carey, Renata Pajtak, Melissa F. Formosa, Bruce Van Every, David A. Bertovic, Mitchell J. Anderson, Nina Eikelis, Gavin W. Lambert, Victor Kalff, Stephen J. Duffy, Martin H. Cherk, Bronwyn A. Kingwell

Obesity-associated intestinal insulin resistance is ameliorated after bariatric surgery
Jaakko Mäkinen, Jarna C. Hannukainen, Anna Karmi, Heidi M. Immonen, Minna Soinio, Lassi Nelimarkka, Nina Savisto, Mika Helmiö, Jari Ovaska, Paulina Salminen, Patricia Iozzo, Pirjo Nuutila

The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo
Shlomit Koren, Lisa M. DiPilato, Matthew J. Emmett, Abigail L. Shearin, Qingwei Chu, Bob Monks, Morris J. Birnbaum

In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice
Sabina Paglialunga, Alison Ludzki, Jared Root-McCaig, Graham P. Holloway

Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats
Christopher Taveau, Catherine Chollet, Ludovic Waeckel, Dorinne Desposito, Daniel G. Bichet, Marie-Françoise Arthus, Christophe Magnan, Erwann Philippe, Valerie Paradis, Fabienne Foufelle, Isabelle Hainault, Sofia Enhorning, Gilberto Velho, Ronan Roussel, Lise Bankir, Olle Melander, Nadine Bouby

DPP-4 inhibition contributes to the prevention of hypoglycaemia through a GIP–glucagon counterregulatory axis in mice
Siri Malmgren, Bo Ahrén

Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol
Heather C. Denroche, Michelle M. Kwon, Whitney L. Quong, Ursula H. Neumann, Jerzy E. Kulpa, Subashini Karunakaran, Susanne M. Clee, Roger W. Brownsey, Scott D. Covey, Timothy J. Kieffer

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Pathophysiology and Complications

Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort
Henna Cederberg, Alena Stancáková, Nagendra Yaluri, Shalem Modi, Johanna Kuusisto, Markku Laakso

Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: the KORA S4 survey
Dan Ziegler, Andreas Voss, Wolfgang Rathmann, Alexander Strom, Siegfried Perz, Michael Roden, Annette Peters, Christa Meisinger, for the KORA Study Group

Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice
Carmel M. McVicar, Micheal Ward, Liza M. Colhoun, Jasenka Guduric-Fuchs, Angelika Bierhaus, Thomas Fleming, Andreas Schlotterer, Matthias Kolibabka, Hans-Peter Hammes, Mei Chen, Alan W. Stitt

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Research Letter

Human islet distribution programme for basic research: activity over the last 5 years
Rita Nano, Domenico Bosco, Julie A. Kerr-Conte, Marie Karlsson, Solange Charvier, Raffaella Melzi, Rimed Ezzouaoui, Alessia Mercalli, Albert Hwa, François Pattou, Olle Korsgren, Thierry Berney, Lorenzo Piemonti

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Retraction Note

Retraction Note: Abstracts of the 50th Annual Meeting of the EASD, Vienna 2014. ‘Evaluation of DiaPep277® treatment in type 1 diabetes by integrated analysis’
D. Elias, A. Avron, M. Tamir, R. Eren, D. Peled, S. Dagan, I. Raz, P. Pozzilli, T. Linn, F. Bonnici, DIA-AID Study Group

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Erratum

Erratum to: Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study
Evangelos Kontopantelis, David A. Springate, David Reeves, Darren M. Ashcroft, Martin K. Rutter, Iain Buchan, Tim Doran

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