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Welcome to Diabetologia

Diabetologia publishes original clinical and experimental research within the field of diabetes. We are interested in papers that convey new information or insight into any aspect of the condition, ranging from basic science to clinical applications. These are judged in terms of their scientific quality, novelty, relevance and interest to our broadly based readership.

Statement of Principle

Joint Statement of Principle from the EASD, ADA, AACE and TES (November 2014)

In the News

Following gestational diabetes, obese women who put on 5 kg are more than 40 times more likely to develop full blown type 2 diabetes

Download this new research by Dr Cuilin Zhang, senior investigator, and Dr Wei Bao, post-doctoral fellow, Eunice Kennedy Shriver National Institute of Child Health and Human Development at the US National Institutes of Health, Rockville, MD, USA, and colleagues.
For further information contact Dr Zhang (zhangcu@mail.nih.gov).


(posted online 22.01h GMT Wednesday 18th March 2015)

Overhaul of European and US medical device safety recommended by the EASD and ADA

Download these recommendations from a joint committee of the European Association for the Study of Diabetes and the American Diabetes Association which are being published simultaneously in Diabetologia and Diabetes Care; the authors include Professor John Petrie, Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK, and Professor Anne Peters, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
For further information contact Professor Petrie (john.petrie@glasgow.ac.uk) and Professor Peters (momofmax@me.com).

See presentations made at the EASD Devices meeting in February 2015 (including presentations about this statement).


(posted online 22.01h GMT Monday 16th March 2015)

Current issue: April 2015

April 2015 cover

Click here to view this month's contents

In the present issue of Diabetologia, Viktor Jörgens and colleagues provide an editorial discussing some of the highlights of the first 50 years of the EASD. Throughout its history, the EASD has seen a veritable Who's who of diabetes research proudly represent the Association as president. Depicted on this month's cover, they are, in reverse chronological order of term: Andrew J. M. Boulton 2011 – present; Ulf Smith, 2008–2011; Ele Ferrannini, 2004–2008; Philippe A. Halban, 2001–2004; Jørn Nerup, 1998–2001; Michael Berger, 1995–1998; George Alberti, 1992–1995; Pierre Lefèbvre, 1989–1992; Pierre Freychet, 1986–1989; Domenico Andreani, 1983–1986; Willy Gepts, 1980–1983; Philip John Randle, 1977–1980; Albert Renold, 1974–1977; Werner Creutzfeldt, 1971–1974; Knud Lundbaek 1968–1971; Frank Young, 1965–1968; and Joseph Hoet, 1965.


Cover credit: EASD

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Up front

Juleen Zierath

Competition for publication in Diabetologia is greater than ever, and less than 20% of papers are accepted. Of all the high-quality papers that appear in this month's issue I want to share with you five articles that I find to be of particular interest. These will be featured 'up front' in the print issue and here on our website. Juleen R. Zierath, Editor


A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase
by Zhi-Chao Feng, Matthew Riopel, Alex Popell, Rennian Wang

Diabetes progression is marked by a decline in pancreatic beta cell mass. Extensive research efforts are focused on developing methods to repopulate insulin-producing beta cells and to maintain their survival and function. In this issue, Feng and colleagues summarise recent advances in the understanding of the physiological role of the stem cell factor-targeted receptor c-Kit. As this receptor is a marker of pancreatic endocrine progenitors across species, differentiation of c-Kit-expressing cells might represent an approach for beta cell replacement. Several in vitro and in vivo knock-in or mutation studies have highlighted the importance of c-Kit in the pancreas, by providing evidence of interplay between c-Kit and other receptors in the pancreas via multiple signalling pathways involved in the control of islet morphogenesis, islet vascularisation, and beta cell survival and function. Taken together, the findings to date indicate that c-Kit may serve as a target for the development of cell-based and novel drug therapies for diabetes mellitus. [Text supplied by the authors.]

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The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy
by Leif Østergaard, Nanna B. Finnerup, Astrid J. Terkelsen, Rasmus A. Olesen, Kim R. Drasbek, Lone Knudsen, Sune N. Jespersen, Jan Frystyk, Morten Charles, Reimar W. Thomsen, Jens S. Christiansen, Henning Beck-Nielsen, Troels S. Jensen, Henning Andersen

The pathophysiological mechanisms underlying diabetic neuropathy are largely unknown. The scientific community has generally been divided into two schools of thought, one of which considers a metabolic mechanism to be most likely, while the other supports a vascular origin of diabetic neuropathy. In this issue, Østergaard and colleagues explain how the supply of oxygen and glucose to tissue is limited not only by its blood supply, but also by the capillary distribution of blood. Consequently, tissue hypoxia can be the result of either reduced blood flow (ischaemia) or capillary dysfunction (functional shunting of oxygenated blood through the capillary bed). The authors discuss evidence of altered capillary morphology in diabetic neuropathy, and whether capillary dysfunction may contribute to the abnormal glucose metabolism and tissue hypoxia observed in peripheral nerves in the disease. They suggest experimental, epidemiological and clinical studies that could be conducted to test this hypothesis. [Text supplied by the authors.]

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Obstetric and perinatal outcome in type 1 diabetes patients with diabetic nephropathy during 1988-2011
by Miira M. Klemetti, Hannele Laivuori, Minna Tikkanen, Mika Nuutila, Vilho Hiilesmaa, Kari Teramo

Pregnant women with diabetic nephropathy are at high risk of hypertensive disorders, preterm birth, intrauterine growth restriction and perinatal mortality. The prognosis of patients with diabetic nephropathy has improved in the past decades, but population-based reports regarding pregnancy outcomes in diabetic nephropathy are lacking. In this issue, Klemetti et al report the results of an analysis of a population-based cohort of 108 type 1 diabetes women with diabetic nephropathy who were followed for over 20 years. Prepregnancy and early pregnancy glycaemic control remained suboptimal and hypertension rates stayed high during 1988-2011. Poor glycaemic control is a risk factor for fetal malformations, pre-eclampsia and preterm delivery, all three of which were common in the cohort throughout the study period. Median HbA1c levels were high prepregnancy and during early pregnancy, but decreased to below 7% (53 mmol/mol) by midpregnancy, suggesting that glycaemic control could be improved before pregnancy with intensified treatment. The high frequency of hypertension observed throughout pregnancy in this cohort suggests that greater efforts should be made to control blood pressure in parturients with diabetic nephropathy. This article is the subject of a commentary in this issue by Elisabeth Mathiesen. [Text supplied by the authors.]

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Night-shift work and incident diabetes among African-American women
by Varsha G. Vimalananda, Julie R. Palmer, Hanna Gerlovin, Lauren A. Wise, James L. Rosenzweig, Lynn Rosenberg, Edward A. Ruiz Narváez

In this issue, Vimalananda et al report a higher risk of incident diabetes among African-American women who did night shift work. The association was stronger for those who had worked night shifts for a greater number of years, and persisted after adjustment for lifestyle factors and BMI. The authors suggest that this is because disruption in the sleep-wake cycle has profound effects on metabolism, due in part to increased loss of beta cell function and mass. The authors acknowledge that, for most shift workers, simply quitting their jobs is not likely to be a feasible option, and suggest that the burden of prevention may therefore lie at a social or employer level, for example, through avoidance of shift work where possible. [Text supplied by the authors.]

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SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes
by Richard E. Gilbert, Kerri Thai, Suzanne L. Advani, Carolyn L. Cummins, David M. Kepecs, Stephanie A. Schroer, Minna Woo, Yanling Zhang

Obesity and insulin resistance underlie the development of type 2 diabetes. These same phenomena are also observed in hibernating mammals as they ready themselves for nutrient deprivation in winter, yet they do not develop hyperglycaemia. Given the role of sirtuin 1 (SIRT1) in survival and life extension during periods of energy deprivation, as reported in this issue, Gilbert and colleagues tested the hypothesis that enhancing SIRT1 activity may alter the obese-insulin-resistant-diabetic phenotype to one that more closely resembles hibernation. Glycaemic control, plasma insulin concentrations and pancreatic islet beta cell mass were greatly improved in an obese diabetic mouse model following the addition of a SIRT1 activator to their diet. However, these mice also showed reduced physical activity and further weight gain. These studies highlight the importance and complexities of the metabolic state in determining the diabetic phenotype, but also indicate that there is potential for this to be pharmacologically manipulated. [Text supplied by the authors.]

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Inside this issue

Editorial

Happy Birthday EASD—50 years of dedication to diabetes research
Viktor Jörgens, Monika Grüsser, Pierre Lefèbvre

Commentaries

Diabetic nephropathy in pregnancy: new insights from a retrospective cohort study
Elisabeth R. Mathiesen

Are we waking up to the effects of NEFA?
Jonathan C. Jun, Vsevolod Y. Polotsky

Reviews

A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase
Zhi-Chao Feng, Matthew Riopel, Alex Popell, Rennian Wang

The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy
Leif Østergaard, Nanna B. Finnerup, Astrid J. Terkelsen, Rasmus A. Olesen, Kim R. Drasbek, Lone Knudsen, Sune N. Jespersen, Jan Frystyk, Morten Charles, Reimar W. Thomsen, Jens S. Christiansen, Henning Beck-Nielsen, Troels S. Jensen, Henning Andersen

Articles

Clinical Science and Care

Obstetric and perinatal outcome in type 1 diabetes patients with diabetic nephropathy during 1988–2011
Miira M. Klemetti, Hannele Laivuori, Minna Tikkanen, Mika Nuutila, Vilho Hiilesmaa, Kari Teramo

Pharmacokinetics of diluted (U20) insulin aspart compared with standard (U100) in children aged 3–6 years with type 1 diabetes during closed-loop insulin delivery: a randomised clinical trial
Short Communication
Yue Ruan, Daniela Elleri, Janet M. Allen, Martin Tauschmann, Malgorzata E. Wilinska, David B. Dunger, Roman Hovorka

Cardiac rehabilitation completion is associated with reduced mortality in patients with diabetes and coronary artery disease
Marni J. Armstrong, Ronald J. Sigal, Ross Arena, Trina L. Hauer, Leslie D. Austford, Sandeep Aggarwal, James A. Stone, Billie-Jean Martin

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Epidemiology

Night-shift work and incident diabetes among African-American women
Varsha G. Vimalananda, Julie R. Palmer, Hanna Gerlovin, Lauren A. Wise, James L. Rosenzweig, Lynn Rosenberg, Edward A. Ruiz Narváez

History of infertility and risk of type 2 diabetes mellitus: a prospective cohort study
Deirdre K. Tobias, Audrey J. Gaskins, Stacey A. Missmer, Frank B. Hu, JoAnn E. Manson, Germaine M. Buck Louis, Cuilin Zhang, Jorge E. Chavarro

Ethnicity and risk of cardiovascular disease (CVD): 4.8 year follow-up of patients with type 2 diabetes living in Scotland
Muhammad Omar Malik, L. Govan, John R. Petrie, Nazim Ghouri, Graham Leese, Colin Fischbacher, Helen Colhoun, Sam Philip, Sarah Wild, Rory McCrimmon, Naveed Sattar, Robert S. Lindsay, on behalf of Scottish Diabetes Research Network (SDRN) Epidemiology group

Plasma isoflavone concentration is associated with decreased risk of type 2 diabetes in Korean women but not men: results from the Korean Genome and Epidemiology Study
Kwang-Pil Ko, Cheong-Sik Kim, Younjhin Ahn, Seon-Joo Park, Yeon-Jeong Kim, Jae Kyung Park, Young-Khi Lim, Keun-Young Yoo, Sung Soo Kim

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Genetics

Haptoglobin genotype modulates the relationships of glycaemic control with cognitive function in elderly individuals with type 2 diabetes
Elizabeth Guerrero-Berroa, Ramit Ravona-Springer, Anthony Heymann, James Schmeidler, Andrew Levy, Derek Leroith, Michal S. Beeri

A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1
Short Communication
Jonathan M. Locke, Fan-Yan Wei, Kazuhito Tomizawa, Michael N. Weedon, Lorna W. Harries

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Islet Studies

Multilevel control of glucose homeostasis by adenylyl cyclase 8
Matthieu Raoux, Pierre Vacher, Julien Papin, Alexandre Picard, Elzbieta Kostrzewa, Anne Devin, Julien Gaitan, Isabelle Limon, Martien J. Kas, Christophe Magnan, Jochen Lang

Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant–mitochondrial response in mouse beta cells
Mohammed Bensellam, Magdalene K. Montgomery, Jude Luzuriaga, Jeng Yie Chan, D. Ross Laybutt

Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure
Yong Kyung Kim, Kyong Hye Joung, Min Jeong Ryu, Soung Jung Kim, Hyeongseok Kim, Hyo Kyun Chung, Min Hee Lee, Seong Eun Lee, Min Jeong Choi, Joon Young Chang, Hyun Jung Hong, Koon Soon Kim, Sang-Hee Lee, Gi Ryang Kweon, Hail Kim, Chul-Ho Lee, Hyun Jin Kim, Minho Shong

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Immunology and Transplantation

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients
Ricardo C. Ferreira, Henry Z. Simons, Whitney S. Thompson, Antony J. Cutler, Xaquin Castro Dopico, Deborah J. Smyth, Meghavi Mashar, Helen Schuilenburg, Neil M. Walker, David B. Dunger, Chris Wallace, John A. Todd, Linda S. Wicker, Marcin L. Pekalski

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Metabolism

Sleep restriction increases free fatty acids in healthy men
Josiane L. Broussard, Florian Chapotot, Varghese Abraham, Andrew Day, Fanny Delebecque, Harry R. Whitmore, Esra Tasali

Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance
Aimo Kannt, Anja Pfenninger, Lenore Teichert, Anke Tönjes, Arne Dietrich, Michael R. Schön, Nora Klöting, Matthias Blüher

Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress
Seong Hun Kim, Kook Hwan Kim, Hyoung-Kyu Kim, Mi-Jeong Kim, Sung Hoon Back, Morichika Konishi, Nobuyuki Itoh, Myung-Shik Lee

SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes
Richard E. Gilbert, Kerri Thai, Suzanne L. Advani, Carolyn L. Cummins, David M. Kepecs, Stephanie A. Schroer, Minna Woo, Yanling Zhang

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Pathophysiology and Complications

The influence of glucagon on postprandial hyperglycaemia in children 5 years after onset of type 1 diabetes
Siri Fredheim, Marie-Louise M. Andersen, Sven Pörksen, Lotte B. Nielsen, Christian Pipper, Lars Hansen, Jens J. Holst, Jane Thomsen, Jesper Johannesen, Henrik B. Mortensen, Jannet Svensson

Analysis of global gene expression profiles suggests a role of acute inflammation in type 3C diabetes mellitus caused by pancreatic ductal adenocarcinoma
Wenchao Gao, Yu Zhou, Qingyan Li, Quanbo Zhou, Langping Tan, Yadong Song, Xiaohui Zhao, Min Yu, Shangyou Zheng, Huilin Ye, Bing Zeng, Qing Lin, Jiajia Zhou, Yimin Liu, Huaiqiu Huang, Hui Zhang, Xuchu Hu, Zhihua Li, Xianhua Dai, Rufu Chen

Protection from diabetes-induced atherosclerosis and renal disease by D-carnosine-octylester: effects of early vs late inhibition of advanced glycation end-products in Apoe-null mice
Stefano Menini, Carla Iacobini, Carlo Ricci, Claudia Blasetti Fantauzzi, Giuseppe Pugliese

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Erratum

Erratum to: Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase
V. B. Matthews, M.-B. Åström, M. H. S. Chan, C. R. Bruce, K. S. Krabbe, O. Prelovsek, T. Åkerström, C. Yfanti, C. Broholm, O. H. Mortensen, M. Penkowa, P. Hojman, A. Zankari, M. J. Watt, H. Bruunsgaard, B. K. Pedersen, M. A. Febbraio

List of Referees

Referees 2014

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