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Welcome to Diabetologia

Diabetologia publishes original clinical and experimental research within the field of diabetes. We are interested in papers that convey new information or insight into any aspect of the condition, ranging from basic science to clinical applications. These are judged in terms of their scientific quality, novelty, relevance and interest to our broadly based readership.

In the News

Study shows that fenofibrate treatment in women with diabetes is as effective as in men with diabetes

Download this new research by Professor Anthony Keech from the Clinical Trials Centre at the University of Sydney, Australia, and Associate Professor Michael d'Emden, Endocrine Research Unit, Royal Brisbane Hospital, Brisbane, Australia and colleagues.
For further information contact Dr d'Emden (Michael.d'Emden@health.qld.gov.au).


(posted online 22.01 h BST Monday 18th August 2014)

Research explores why interval walking training is better than continuous walking training for glucose metabolism in people with diabetes

Download this new research by Dr Thomas Solomon, University of Copenhagen, Denmark, and colleagues.
For further information contact Dr Solomon (thomas.solomon@sund.ku.dk).

(posted online 23.01 h BST Monday 4th August 2014)

Current issue: September 2014

September 2014 cover

Click here to view this month's contents

The cover picture shows a high-resolution micrograph of an in vitro culture system for vasculogenesis and angiogenesis (explant culture using para-aortic splanchnopleural mesoderm that contains immature endothelial progenitors). The blue stain shows vascular endothelial cells, and brown indicates vascular smooth muscle. The addition of selenoprotein P, a hepatokine upregulated in type 2 diabetes, selectively decreased the numbers of endothelial cells. In the present issue of Diabetologia Ishikura et al provide evidence that selenoprotein P impairs angiogenesis by inducing vascular endothelial growth factor (VEGF) resistance in vascular endothelial cells.

Cover credit: H.MISU, K.ISHIKURA AND T.TAKAMURA, KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES, ISHIKAWA, JAPAN; N.TAKAKURA, OSAKA UNIVERSITY, OSAKA, JAPAN

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Up front

Juleen Zierath

Competition for publication in Diabetologia is greater than ever, and less than 20% of papers are accepted. Of all the high-quality papers that appear in this month's issue I want to share with you five articles that I find to be of particular interest. These will be featured 'up front' in the print issue and here on our website. Juleen R. Zierath, Editor


ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion
by Patrik Rorsman, Reshma Ramracheya, Nils J. G. Rorsman, Quan Zhang

The regulation of glucagon secretion in alpha cells and the relative contributions of intrinsic vs paracrine mechanisms remain hotly debated. In this issue, Rorsman et al consider whether glucagon secretion is regulated by intrinsic processes culminating in glucose-induced closure of alpha cell ATP-regulated potassium channels (KATP channels). The paradox that closure of KATP channels inhibits glucagon secretion in alpha cells, but stimulates insulin secretion in beta cells, can be resolved by the fact that the resting KATP channel activity in alpha cells exposed to low glucose is very low, so that effects of membrane depolarisation acting further downstream will predominate over the stimulation of electrical activity, resulting in a net reduction of glucagon release. These observations raise the interesting possibility that a common cellular disorder resulting in impaired KATP channel activity in alpha and beta cells explains the two cardinal features of type 2 diabetes: low insulin secretion and high glucagon secretion. [Text supplied by the authors.]

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Peptide YY: more than just an appetite regulator
by Shanta J. Persaud and Gavin A. Bewick

The most prominent role of the gut hormone peptide YY (PYY) has generally been considered to be its contribution to the maintenance of body weight by acting as a satiety-inducing factor released after food intake. In this issue, a review by Persaud and Bewick draws on their recently published data suggesting that PYY, and the neuropeptide Y (NPY) receptors through which it acts, may also be important regulators of beta cell mass and function. This article provides a comprehensive review of our current knowledge of the roles of PYY and NPY receptors in the control of insulin release and islet development and regeneration, whilst also exploring the merits of targeting these receptors to stimulate proliferation and prevent apoptosis in beta cells. This information could act as a springboard for further research aimed at identifying NPY receptors as bona fide novel targets for the prevention or treatment of diabetes. [Text supplied by the authors.]

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Impact of different training modalities on glycaemic control and blood lipids in patients with type 2 diabetes: a systematic review and network meta-analysis
by Lukas Schwingshackl, Benjamin Missbach, Sofia Dias, Jürgen König, Georg Hoffmann

It is well established that any form of exercise is better than doing nothing, with regard to glucose control. However, an important question that remains is which exercise modality offers the greatest benefit. In this issue, a meta-analysis by Schwingshackl et al suggests that, in patients with established type 2 diabetes, aerobic training is more effective in reducing HbA1c and fasting glucose levels when compared with resistance training. Combined aerobic and resistance training was more powerful in reducing HbA1c than aerobic training alone, and more effective in reducing HbA1c, fasting glucose and triacylglycerol than resistance training alone. However, these results could not be confirmed when the meta-analysis was restricted to studies with a low risk of bias. Further high quality long-term exercise interventions, with hard clinical endpoints (such as cardiovascular disease or mortality) are needed to develop definitive recommendations. In the meantime, combined aerobic and resistance training can be recommended as part of a lifestyle programme in the management of type 2 diabetes. [Text supplied by the authors.]

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Effects of calcium–vitamin D co-supplementation on glycaemic control, inflammation and oxidative stress in gestational diabetes: a randomised placebo-controlled trial
by Zatollah Asemi, Maryam Karamali, Ahmad Esmaillzadeh

Calcium and vitamin D are thought to act jointly rather than independently; however, few studies have examined the influence of calcium–vitamin D co-supplementation on the metabolic status of pregnant women with gestational diabetes (GDM). In this issue, Asemi et al hypothesised that joint calcium–vitamin D supplementation would be more efficient in influencing metabolic profiles than single supplementation. In this study, calcium–vitamin D supplementation among women with GDM was associated with an improved glycaemic status, a significant decrease in serum LDL-cholesterol, and a significant rise in HDL-cholesterol and plasma glutathione concentrations, but did not affect the profiles of other lipids and inflammatory factors. These findings may help to decrease short- and long-term health complications for the mother, fetus and neonate. This article is the subject of a commentary in this issue by Burris et al. [Text supplied by the authors.]

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Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trial
by Daniela Jakubowicz, Oren Froy, Bo Ahrén, Mona Boaz, Zohar Landau, Yosefa Bar-Dayan, Tali Ganz, Maayan Barnea, Julio Wainstein

High milk intake has been associated with lower risk for type 2 diabetes and a possible protective mechanism has been ascribed to the whey protein fraction. Protein, and particularly whey protein, which accounts for 20% of whole-milk protein, increases the production of glucagon-like peptide-1 (GLP-1), a gut hormone that stimulates insulin secretion, which in turn reduces blood glucose levels after meals. It was therefore hypothesised that consumption of whey protein before breakfast would increase insulin secretion and reduce the post-meal rise in blood glucose in individuals with type 2 diabetes. In this issue, Jakubowicz et al provide evidence that, in type 2 diabetic individuals, whey protein pre-load increases post-meal GLP-1 and the early insulin response, usually deficient in type 2 diabetes, leading to reduced blood glucose. Whey protein may, therefore, represent a novel strategy to lower post-meal glucose levels in people with type 2 diabetes. [Text supplied by the authors.]

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Inside this issue

Commentaries

Evidence-based estimation of insulin resistance
John R. Petrie

Time for large randomised trials of vitamin D for women with gestational diabetes mellitus to improve perinatal health outcomes
Heather H. Burris, Carlos A. Camargo Jr

Reviews

ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion
Patrik Rorsman, Reshma Ramracheya, Nils J. G. Rorsman, Quan Zhang

Peptide YY: more than just an appetite regulator
Shanta J. Persaud, Gavin A. Bewick

Dietary gluten and the development of type 1 diabetes
Julie C. Antvorskov, Knud Josefsen, Kåre Engkilde, David P. Funda, Karsten Buschard

Meta-analyses

Surrogate measures of insulin sensitivity vs the hyperinsulinaemic–euglycaemic clamp: a meta-analysis
Julia Otten, Bo Ahrén, Tommy Olsson

Impact of different training modalities on glycaemic control and blood lipids in patients with type 2 diabetes: a systematic review and network meta-analysis
Lukas Schwingshackl, Benjamin Missbach, Sofia Dias, Jürgen König, Georg Hoffmann

Articles

Clinical Science and Care

Effects of calcium–vitamin D co-supplementation on glycaemic control, inflammation and oxidative stress in gestational diabetes: a randomised placebo-controlled trial
Zatollah Asemi, Maryam Karamali, Ahmad Esmaillzadeh

Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trial
Short Communication
Daniela Jakubowicz, Oren Froy, Bo Ahrén, Mona Boaz, Zohar Landau, Yosefa Bar-Dayan, Tali Ganz, Maayan Barnea, Julio Wainstein

Liraglutide reverses pronounced insulin-associated weight gain, improves glycaemic control and decreases insulin dose in patients with type 2 diabetes: a 26 week, randomised clinical trial (ELEGANT)
Helena M. de Wit, Gerald M. M. Vervoort, Henry J. Jansen, Wim J. C. de Grauw, Bastiaan E. de Galan, Cees J. Tack

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Epidemiology

Eighteen year weight trajectories and metabolic markers of diabetes in modernising China
Penny Gordon-Larsen, Elizabeth Koehler, Annie Green Howard, Lauren Paynter, Amanda L. Thompson, Linda S. Adair, Elizabeth J. Mayer-Davis, Bing Zhang, Barry M. Popkin, Amy H. Herring

Association of genetic predisposition to obesity with type 2 diabetes risk in Han Chinese individuals
Short Communication
Jingwen Zhu, Geng Zong, Ling Lu, Wei Gan, Linong Ji, Renming Hu, Xingwang Ye, Liang Sun, Ruth J. F. Loos, Huaixing Li, Xu Lin

Lipopolysaccharide binding protein, obesity status and incidence of metabolic syndrome: a prospective study among middle-aged and older Chinese
Xin Liu, Ling Lu, Pang Yao, Yiwei Ma, Feijie Wang, Qianlu Jin, Xingwang Ye, Huaixing Li, Frank B. Hu, Liang Sun, Xu Lin

Circulating peroxiredoxin 4 and type 2 diabetes risk: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study
Ali Abbasi, Eva Corpeleijn, Ron T. Gansevoort, Rijk O. B. Gans, Joachim Struck, Janin Schulte, Hans L. Hillege, Pim van der Harst, Ronald P. Stolk, Gerjan Navis, Stephan J. L. Bakker

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Genetics

Association of African genetic ancestry with fasting glucose and HbA1c levels in non-diabetic individuals: the Boston Area Community Health (BACH) Prediabetes Study
James B. Meigs, Richard W. Grant, Rebecca Piccolo, Lenny López, Jose C. Florez, Bianca Porneala, Lisa Marceau, John B. McKinlay

Type 2 diabetes susceptibility gene variants predispose to adult-onset autoimmune diabetes
Mette K. Andersen, Maria Sterner, Tom Forsén, Annemari Käräjämäki, Olov Rolandsson, Carol Forsblom, Per-Henrik Groop, Kaj Lahti, Peter M. Nilsson, Leif Groop, Tiinamaija Tuomi

Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin
Heike Zimdahl, Carina Ittrich, Ulrike Graefe-Mody, Bernhard O. Boehm, Michael Mark, Hans-Juergen Woerle, Klaus A. Dugi

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Islet Studies

Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes
Bilal A. Omar, Liu Liehua, Yuchiro Yamada, Yutaka Seino, Piero Marchetti, B. Ahrén

Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice
Short Communication
Daniel T. Meier, Mary Morcos, Thanya Samarasekera, Sakeneh Zraika, Rebecca L. Hull, Steven E. Kahn

Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions
Linyuan Wang, Cynthia T. Luk, Stephanie A. Schroer, Alannah M. Smith, Xie Li, Erica P. Cai, Herbert Gaisano, Patrick E. MacDonald, Zhenyue Hao, Tak W. Mak, Minna Woo

A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1
Hong-Mei Wang, Jun-Hong Dong, Qing Li, Qiaoxia Hu, Shang-Lei Ning, Wenshuai Zheng, Min Cui, Tian-Sheng Chen, Xin Xie, Jin-Peng Sun, Xiao Yu

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Immunology and Transplantation

GAD autoantibody affinity in schoolchildren from the general population
Christine Bender, Michael Schlosser, Urs Christen, Anette G. Ziegler, Peter Achenbach

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Metabolism

Hyperglucagonaemia analysed by glucagon sandwich ELISA: nonspecific interference or truly elevated levels?
Nicolai J. Wewer Albrechtsen, Bolette Hartmann, Simon Veedfald, Johanne A. Windeløv, Astrid Plamboeck, Kirstine N. Bojsen-Møller, Thomas Idorn, Bo Feldt-Rasmussen, Filip K. Knop, Tina Vilsbøll, Sten Madsbad, Carolyn F. Deacon, Jens J. Holst

A novel DPP IV-resistant C-terminally extended glucagon analogue exhibits weight-lowering and diabetes-protective effects in high-fat-fed mice mediated through glucagon and GLP-1 receptor activation
Aisling M. Lynch, Nupur Pathak, Varun Pathak, Finbarr P. M. O’Harte, Peter R. Flatt, Nigel Irwin, Victor A. Gault

Independent effects of circulating glucose, insulin and NEFA on cardiac triacylglycerol accumulation and myocardial insulin resistance in a swine model
Maria Angela Guzzardi, Leanne Hodson, Letizia Guiducci, Elena Sanguinetti, Pietro Di Cecco, Tiziana Liistro, Cristina Vassalle, Silvia Pardini, Lucia Giorgetti, Piero A. Salvadori, Silvia Burchielli, Patricia Iozzo

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Pathophysiology and Complications

The molecular signature of impaired diabetic wound healing identifies serpinB3 as a healing biomarker
Gian Paolo Fadini, Mattia Albiero, Renato Millioni, Nicol Poncina, Mauro Rigato, Rachele Scotton, Federico Boscari, Enrico Brocco, Giorgio Arrigoni, Gianmarco Villano, Cristian Turato, Alessandra Biasiolo, Patrizia Pontisso, Angelo Avogaro

Fine-tuned iron availability is essential to achieve optimal adipocyte differentiation and mitochondrial biogenesis
José María Moreno-Navarrete, Francisco Ortega, María Moreno, Wifredo Ricart, José Manuel Fernández-Real

Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells
Kazuhide Ishikura, Hirofumi Misu, Masafumi Kumazaki, Hiroaki Takayama, Naoto Matsuzawa-Nagata, Natsumi Tajima, Keita Chikamoto, Fei Lan, Hitoshi Ando, Tsuguhito Ota, Masaru Sakurai, Yumie Takeshita, Kenichiro Kato, Akio Fujimura, Ken-ichi Miyamoto, Yoshiro Saito, Satomi Kameo, Yasuo Okamoto, Yoh Takuwa, Kazuhiko Takahashi, Hiroyasu Kidoya, Nobuyuki Takakura, Shuichi Kaneko, Toshinari Takamura

Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes
Greg Tesch, Karly C. Sourris, Shaun A. Summers, Domenica McCarthy, Micheal S. Ward, Danielle J. Borg, Linda A. Gallo, Amelia K. Fotheringham, Allison R. Pettit, Felicia Y. T. Yap, Brooke E. Harcourt, Adeline L. Y. Tan, Joshua Y. Kausman, David Nikolic-Paterson, Arthur R. Kitching, Josephine M. Forbes

Maternal diabetes modulates kidney formation in murine progeny: the role of hedgehog interacting protein (HHIP)
Xin-Ping Zhao, Min-Chun Liao, Shiao-Ying Chang, Shaaban Abdo, Yessoufou Aliou, Isabelle Chenier, Julie R. Ingelfinger, Shao-Ling Zhang

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Research Letter

Fate of abstracts submitted to the 2004 EASD Annual Meeting in Munich
Viktor Jörgens, Monika Grüsser, Philipp Schürmann, Ulrich A. Müller

Letters

Severity of heart failure and risk of incident diabetes: a reverse causation?
Bao-Tao Huang, Mao Chen

Mortality after cancer among patients with diabetes mellitus: effect of diabetes duration and treatment: (questionable) classification of diabetic patients based on combination of specific glucose-lowering drugs
Sarah E. Holden, Christian A. Bannister, Craig J. Currie

Mortality after cancer among patients with diabetes mellitus: effect of diabetes duration and treatment: (questionable) classification of diabetic patients based on combination of specific glucose-lowering drugs. Reply to Holden SE, Bannister CA, Currie CJ [letter]
Kristina Ranc, Marit E. Jørgensen, Søren Friis, Bendix Carstensen

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Erratum

Erratum to: Eighteen year weight trajectories and metabolic markers of diabetes in modernising China
Penny Gordon-Larsen, Elizabeth Koehler, Annie Green Howard, Lauren Paynter, Amanda L. Thompson, Linda S. Adair, Elizabeth J. Mayer-Davis, Bing Zhang, Barry M. Popkin, Amy H. Herring

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