The cover picture shows the ligand-binding domain co-crystal structure of human peroxisome proliferator-activated receptor delta (PPAR-delta) with the synthetic agonist GW501516 located in the ligand pocket (AF-2 helix in red; ligand in green; ligand pocket in grey). HDL-raising and insulin-sensitising properties of PPAR-delta agonists such as GW501516, which is in clinical development, are summarised in a review article by Fürnsinn et al. in this issue of Diabetologia (50: 8-17).
Image supplied by T. Willson.