The cover image shows red endothelial progenitor cells (EPCs) adhering to green human umbilical vein endothelial cells (artificial colours, 2000x magnification). EPCs provide a circulating reservoir for replacement of damaged endothelium. Their adhesion to the mature endothelial layer is a key event in maintenance of endothelial homeostasis. Functional or quantitative abnormalities of EPCs herald the development of endothelial dysfunction and atherosclerosis in diabetes and prediabetes. See Fadini et al (50: 2156-2163) and a Commentary by Hanley (50: 2033-2035).
Cover credit: G.P. Fadini and M. Albiero, University of Padova, Medical School, Padova, Italy