The cover picture shows a high-magnification double-immunofluorescence micrograph of CD3 T cells (red) in a pancreas-draining lymph node of an insulin-dependent diabetic rat (LEW.1AR1-iddm; an animal model of human type 1 diabetes). The protein content of the anti-inflammatory cytokine IL-4 (green) is shown as an overlay. The density of T cells co-expressing IL-4 (yellow) is increased in animals that are protected against diabetes. In the present issue of Diabetologia (52: 1381–1390) Arndt et al. report that after transfer of CD8 T cells the insulin-dependent diabetic rats are protected against diabetes manifestation, and that the immune cells in the pancreas-draining lymph nodes show a shift to anti-inflammatory cytokines.
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Cover credit: A. Jörns, Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany