The cover features a false-colour SEM of immature red and white cells within the bone marrow microenvironment. Recent studies have shown that the bone marrow harbours progenitor cells that contribute to the homeostasis of several tissues. This contribution is not limited to the haematopoietic system and includes the vasculature. Altered regulation of these precursor cells may predispose individuals to diabetic complications. In the present issue of Diabetologia (54:945–953), Albiero et al. show that the contribution of bone marrow-derived cells at sites of wound healing is significantly compromised in streptozotocin-induced diabetic mice compared with that in controls. Thus, the bone marrow emerges as a hitherto neglected target of glucotoxicity that may underlie the development of micro- and macroangiopathy.
Cover credit: PHOTO INSOLITE REALITE/SCIENCE PHOTO LIBRARY
Download the high resolution cover image